Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...

Selective targeting of up-regulated integrins on tumor cells is a novel antiangiogenesis strategy for treating solid tumors. CNTO 95 is a fully human anti-alpha(v) integrin monoclonal antibody and has shown antitumor activity when used as a single agent in preclinical studies. We previously showed that radiation combined with an integrin alpha(v)beta(3) antagonist cRGD peptide increased the the...

It is suspected that radiation retinopathy is more likely to develop in an eye with preexisting diabetic retinopathy than in a normal eye. However, there is only one report of this occurring, at a radiation dose of 4500 rads. We present a woman with minimal diabetic retinopathy who had breast carcinoma which was treated with chemotherapy but metastasised to the choroid. Within nine months of ex...

Radiation treatment in the management of pituitary adenoma in children is still a controversy due to the great concern of late radiation effect. Stereotactic radiation therapy is the modern radiation technique that is more widely applicable in pituitary adenoma because of the ability to give highly conformal radiation to the target organ and to reduce the radiation dose to normal tissue. A 15-y...

Buratovic, S. 2015. Neonatal Exposure to Low-Dose Ionizing Radiation in Mice: Developmental neurotoxic effects of single and fractionated doses and interaction with nicotine. 38 pp. Uppsala This thesis aims to investigate the developmental neurotoxic effects of low-dose exposure to ionizing radiation, alone or together with nicotine, during a defined critical period of neonatal brain developmen...

Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...

Meningioma rarely gives rise to metastases outside the brain and meninges. We report here a case of a patient who was treated for anaplastic brain meningioma with surgery and fractionated radiation therapy without any recurrence until 5 years after the operation, when she developed vertebral metastases.

A common side effect of radiotherapy used in the treatment of oral cancer is the occurrence of structural and physiological alterations of the salivary glands due to exposure to ionizing radiation, as demonstrated by conditions such as decreased salivary flow. The present study evaluated ultrastructural alterations in the parotid glands of rats receiving a fractionated dose (1,500-cGy) of radia...

As a continuation of a previous controlled trial using "high-dose" metronidazole as a specific sensitizer of hypoxic cells, we used a more efficient nitroimidazole derivative (misonidazole, MISO) in combination with higher doses of radiation in patients with supratentorial high-grade astrocytomas. Sixty-six patients were stratified according to functional level and histological grading, and ran...