Fragile sites are specific regions of chromosomes that are prone to breakage. In cells cultured under conditions that induce fragile site expression, high levels of inter- and intrachromosomal recombination have been observed involving chromosomal bands containing fragile sites. To determine whether expression of specific fragile sites would facilitate preferential integration of exogenous DNA ...

I T IS NOW WELL established that human tumors, particularly leukemias and lymphomas, are characterized by nonrandom chromosomal abnormalities. During the past 2 years, a number of proto-oncogenes and transforming genes have been mapped to the chromosomal breakpoints involved in the specific structural rearrangements. Experimental evidence obtained recently suggests that the genes located at the...

The present paper summarizes our existing database on chromosomal abnormalities found in patients referred because of a question of the Fragile X Syndrome during the period from January 1, 1990 to June 30, 1995. Cytogenetic results were derived from testing performed at the cytogenetics laboratory at Rhode Island Hospital. All positive fragile X individuals detected among our sample population ...

The following points were made during the Discussion that followed the paper by Brian Martin.

We show that the spectrum of a complete submanifold properly immersed into a ball of a Riemannian manifold is discrete, provided the norm of the mean curvature vector is sufficiently small. In particular, the spectrum of a complete minimal surface properly immersed into a ball of R is discrete. This gives a positive answer to a question of Yau [22].

Documentary heritage reflects the diversity of languages, peoples and cultures. It is the mirror of the world and its memory. But this memory is fragile. Every day, irreplaceable parts of this memory disappear for ever. A considerable proportion of the world's documentary heritage disappears through ‘natural’ causes: acidified paper crumbles away, leather, parchment, film and magnetic tape are ...

The Thessaloniki Summit of 2003 offered perspective to all countries of the Western Balkans to become members of the European Union once they meet necessary conditions. To facilitate the Western Balkans’ accession, the EU has devised specific instruments in addition to those already part of the enlargement strategy. The reason for tailor-making efforts stems from concerns over stability in the ...

in this research using gis effect of land management and soil criteria with eight indicators to study the sensitivity to the desert lands of the region of sistan jazinak creation is evaluated. vote based on the model parameters wilderness - the latest creation esas evaluation method wilderness creation and in most european countries and the middle east is used, took place. using the above metho...

Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotype...