Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

introduction: manipulation of protein stability is important for understanding the principles that govern protein thermostability, both in basic research and industrial applications. various data mining techniques exist for prediction of thermostable proteins. furthermore, ann methods have attracted significant attention for prediction of thermostability, because they constitute an appropriate ...

The expected best residue-by-residue accuracies for secondary structure prediction from multiple protein sequence alignment have been determined by an analysis of known protein structural families. The results show substantial variation is possible among homologous protein structures, and that 100% agreement is unlikely between a consensus prediction and one member of a protein structural famil...

Several pathogenic bacteria are able to induce the attaching and effacing (A/E) lesion. The A/E lesion is caused by effector proteins, such as Escherichia coli-secreted protein B (EspB), responsible together with Escherichia coli-secreted protein D for forming a pore structure on the host cell, which allows the translocation of effector proteins. Different variants of this protein can be found ...

In the near future, design of a new generation of drugs targeting proteins will be required. Considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. So far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. In these studies, use of spectroscopic method...

viroids are smallest, single-stranded, circular, highly structured plant pathogenic rnas that do not code for any protein. viroids belong to two families, the avsunviroidae and the pospiviroidae. members of the pospiviroidae family adopt a rod-like secondary structure. in this study the most stable secondary structures of citrus viroid variants that reported from fars province were drawn. the m...

glutathione transferases are multifunctional proteins involved in several diverse intracellular events such as primary and secondary metabolisms, signaling and stress metabolism. these enzymes have been subdivided into eight classes in plants. the phi class, being plant specific, is the most represented. in the present study, based on the sequences available at genbank, different primers were d...