نتایج جستجو برای: functionalization mnps

تعداد نتایج: 10847  

Journal: :Analytical biochemistry 2009
Hongna Liu Song Li Lishang Liu Lan Tian Nongyue He

To fulfill the increasing need for large-scale genetic research, we have developed a new solid-phase single base extension (SBE) protocol on magnetic nanoparticles (MNPs) for multiplex SNP detection using adapter polymerase chain reaction (PCR) products as templates. Extension primers were covalently immobilized on the MNPs, and allele-specific extension took place along the stretch of target D...

2011
Jun Wang Baoan Chen Nan Jin Guohua Xia Yue Chen Ying Zhou Xiaohui Cai Jiahua Ding Xiaomao Li Xuemei Wang

The aim of this article is to study the changes inhibited T lymphocytes and cytokines related to the cellular immunity in ICR (imprinting control region) mice fed with Fe(3)O(4) magnetic nanoparticles (Fe(3)O(4)-MNPs). The Fe(3)O(4)-MNPs were synthesized, and their characteristics such as particle size, zeta potential, and X-ray diffraction patterns were measured and determined. All ICR mice we...

2009
Baoan Chen Yiqiong Liang Weiwei Wu Jian Cheng Guohua Xia Feng Gao Jiahua Ding Chong Gao Zeye Shao Guohong Li Wenji Chen Wenlin Xu Xinchen Sun Lijie Liu Xiaomao Li Xuemei Wang

Gambogic acid (GA) has a significant anticancer effect on a wide variety of solid tumors. Recently, many nanoparticles have been introduced as drug-delivery systems to enhance the efficiency of anticancer drug delivery. The aim of this study was to investigate the potential benefit of combination therapy with GA and magnetic nanoparticles of Fe(3)O(4) (MNPs-Fe(3)O(4)). The proliferation of K562...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2012
Seong Deok Kong Jisook Lee Srinivasan Ramachandran Brian P Eliceiri Veronica I Shubayev Ratnesh Lal Sungho Jin

Delivery of therapeutic or diagnostic agents across an intact blood-brain barrier (BBB) remains a major challenge. Here we demonstrate in a mouse model that magnetic nanoparticles (MNPs) can cross the normal BBB when subjected to an external magnetic field. Following a systemic administration, an applied external magnetic field mediates the ability of MNPs to permeate the BBB and accumulate in ...

Journal: :Nanoscale 2013
Roxanne Hachani Mark Lowdell Martin Birchall Nguyen Thi Kim Thanh

The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this through the development of inorganic magnetic nanoparticles (MNPs). MNPs can be used to label and tr...

Journal: :Journal of biomedical nanotechnology 2013
Yongjun Tang Zhiyang Li Nongyue He Liming Zhang Chao Ma Xiaolong Li Chuanyan Li Zhifei Wang Yan Deng Lei He

A rapid detection method of Pseudomonas aeruginosa based on magnetic separation and chemiluminescence was developed in this paper. Magnetic nanoparticles (MNPs) were prepared by solvothermal method with PEG-4000 as a surfactant, and then were modified. The prepared MNPs present a uniform morphology and good dispersion. The sizes of MNPs can be controlled by adjusting the dosage of FeCl3 x 6H2O....

Journal: :Molecules 2017
Juan Zhang Hua Zhang Luis Alexandre Muehlmann Cheng-Shi Jiang Yue-Wei Guo

In the last decades, marine natural products (MNPs), have attracted extensive interest from both chemists and pharmacologists due to their chemical and bioactive diversities. This special issue, collecting total synthesis and structural modification of six different type of bioactive MNPs, is expected to inspire and attract more research effects invested into MNP research.

2017
Tao Su Ya-Bin Wang Dong Han Jing Wang Shun Qi Lei Gao Ya-Hui Shao Hong-Yu Qiao Jiang-Wei Chen Shu-Hui Liang Yong-Zhan Nie Jia-Yi Li Feng Cao

Background and Aims: Angiogenesis is an important pathological process during progression of plaque formation, which can result in plaque hemorrhage and vulnerability. This study aims to explore non-invasive imaging of angiogenesis in atherosclerotic plaque through magnetic resonance imaging (MRI) and positron emission tomography (PET) by using GEBP11 peptide targeted magnetic iron oxide nanopa...

2012
Silvia Panseri Carla Cunha Teresa D’Alessandro Monica Sandri Gianluca Giavaresi Maurilio Marcacci Clark T Hung Anna Tampieri

BACKGROUND Superparamagnetic nanoparticles (MNPs) have been progressively explored for their potential in biomedical applications and in particular as a contrast agent for diagnostic imaging, for magnetic drug delivery and more recently for tissue engineering applications. Considering the importance of having safe MNPs for such applications, and the essential role of iron in bone remodelling, t...

Journal: :Soft matter 2015
Lei Duan Fang Yang Lina Song Kun Fang Jilai Tian Yijun Liang Mingxi Li Ning Xu Zhongda Chen Yu Zhang Ning Gu

Magnetic microbubbles (MMBs) consisting of microbubbles (MBs) and magnetic nanoparticles (MNPs) were synthesized for use as novel markers for improving multifunctional biomedical imaging. The MMBs were fabricated by assembling MNPs in different concentrations on the surfaces of MBs. The relationships between the structure, magnetic properties, stability of the MMBs, and their use in magnetic re...

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