Janus silica nanoparticles, regioselectively functionalized by two different chemical groups, were synthesized through a multistep procedure based on the use of a polystyrene nodule as a protecting mask.

Gold nanoparticles functionalized with pro-apoptotic peptide (PAP-AuNPs) were fabricated, which were able to lead to programmed cell-death by damaging mitochondria.

The introduction of a disulfide functionalized tetraphosphonate cavitand on Au nanoparticles promotes the reversible self-assembly of a hybrid network upon addition of a polymeric ditopic guest.

This paper describes the development of an efficient transfection vehicle for nucleic acids using surface-functionalized gold nanoparticles (AuNPs) with a mixed-monolayer of biological molecules—a hybrid approach that combines two previously investigated models. The objective is to improve upon previously described nanoparticles used to introduce nucleic acids to cells—oligonucleotide-functiona...

BACKGROUND Increasing use of silver nanoparticles (Ag-NPs) in various products is resulting in a greater likelihood of human exposure to these materials. Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles. METHODS Ag-NPs functionalized with three different monosaccharides and ethylene glycol were synthesized and charac...

We develop coarse-grained models that describe the dynamic encapsidation of functionalized nanoparticles by viral capsid proteins. We find that some forms of cooperative interactions between protein subunits and nanoparticles can dramatically enhance rates and robustness of assembly, as compared to the spontaneous assembly of subunits into empty capsids. For large core-subunit interactions, sub...

Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4'-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activi...

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate p...

In this paper, the effect of nanocatalytic metal-organic framework based on copper metal and bis-tetrazolamine (CuBTA) ligand functionalized with cobalt (II) oxide nanoparticles on the thermal decomposition behavior of ammonium perchlorate (AP), using differential survey calorimetry (DSC) has been reviewed. First, the metal-organic framework (CuBTA) was synthesized from the raw materials of cop...

Magnetic nanoparticles functionalized with thermoresponsive polymers become photoresponsive when attached to plasmonic nanoparticles to form heterodimers. Under solar illumination, the plasmonic particles absorb sunlight and induce localized heating, causing collapse of the thermoresponsive polymer chain and clustering of the dimers that facilitate magnetic separation.