The Fifth Decennial International Conference on Healthcare-Associated Infections, held March 2010 in Atlanta, Georgia, USA, brought the issue of antimicrobial drug resistance to the forefront. Results of a survey that polled members of the Society for Healthcare Epidemiology of America regarding critical knowledge gaps and research priorities were presented. Respondents reported that 3 of the 5...

The recent outbreak of fungal meningitis caused by Exserohilum rostratum in patients receiving contaminated steroid injections resulted in 64 deaths, receiving a lot of press and briefly bringing into the public eye the difficulty of treating systemic fungal infections [1]. What is generally less well appreciated, however, is that there are several other, much more common fungal pathogens that ...

objectives in this study, we aimed to determine the prevalence of the species of campylobacter. jejuni in zahedan, a major city in southeastern iran. patients and methods fecal samples from 164 patients with acute diarrhea from zahedan hospitals were collected from 2011 to 2013. then the samples were streaked onto a campylobacter selective agar containing supplement and 7% defibrinated sheep bl...

the emergence of multi-drug resistant strains of pseudomonas aeruginosa has complicated treatment decision and may lead to treatment failures. in this study, we describe the trends of drug-resistant p. aeruginosa isolated in blood cultures from patients detected in a tertiary teaching hospital and evaluated the prevalence of resistance to amikacin, ampicillin, carbeni- cillin, cefixime, cefotax...

pseudomonas aeruginosa is one of the most important pathogens that causes nosocomial infections and shows high level of antibiotic resistance. integrons are one of the transposable elements in bacteria and their role in antibiotic resistance has been well demonstrated. the aim of this study was a molecular characterization of the integron genes and the determination of the resistance or sensiti...

introduction: as far as application of chemicals as disinfectants may have side effects on human health and causes drug resistance, the topic of herbal and natural products has been investigated in recent researches. nevertheless, application of medicinal smokes in the treatment of many diseases, including bacterial and infectious diseases has long been popular in iran. smoke from the burning o...

conclusions the results of this study indicated that a decrease in oprd gene expression is an important mechanism of resistance in carbapenem resistant pseudomonas aeruginosa isolated from severe burn patients with secondary infection. results our study showed that 94.2% of the isolates were resistant to imipenem, 99.5% to meropenem, and all were resistant to ertapenem. the oprd gene expression...

background: campylobacter infections may lead to serious conditions, including septicemia or other invasive forms of the disease, which require rapid and accurate laboratory diagnosis and subsequently appropriate antimicrobial therapy. the aim of this study was to compare the species distribution and antimicrobial susceptibility pattern of campylobacter spp. strains isolated from patients and f...

The tangerine pathotype of Alternaria alternata is a necrotrophic fungal pathogen causing brown spot disease on a number of citrus cultivars. To better understand the dynamics of signal regulation leading to oxidative and osmotic stress response and fungal infection on citrus, phenotypic characterization of the yeast SSK1 response regulator homolog was performed. It was determined that SSK1 res...

Cryptococcus neoformans is a pathogenic yeast that causes lethal cryptococcal meningitis in immunocompromised patients. One of the challenges in treating cryptococcosis is the development of resistance to azole antifungals. Previous studies linked azole resistance to elevated numbers of copies of critical resistance genes in aneuploid cells. However, how aneuploidy is formed in the presence of ...