BACKGROUND Acromegaly is a rare, slowly progressive disorder resulting from excessive growth hormone (GH) production by a pituitary somatotroph tumor. The objective of this study was to examine acromegaly treatment outcomes during long-term care at a specialized pituitary center in patients presenting with lack of biochemical control. METHODS Data came from an acromegaly registry at the Cedar...

Consider a testing problem for the null hypothesis H0 : θ ∈ Θ0. The standard frequentist practice is to reject the null hypothesis when the pvalue is smaller than a threshold value α, usually 0.05. We ask the question how many of the null hypotheses a frequentist rejects are actually true. Precisely, we look at the Bayesian false discovery rate δn = Pg(θ ∈ Θ0|p − value < α) under a proper prior...

background herpes simplex virus 1 (hsv-1) resistance to drugs and the side effects of drugs have drawn the attention of investigators to herbal plants. objectives the main aim of the current research was to investigate the effects of glycyrrhiza glabra (liquorice root) on hsv-1. one of the objectives of the current research was to determine the efficacy and the effect of the elapsed incubation ...

BACKGROUND Do colorectal cancer patients with hyperbilirubinemia and liver metastases benefit from chemotherapy? METHODS/RESULTS This study entailed a review of 3,019 consecutive patients with colorectal cancer. Within this cohort, 20 met the study's a priori selection criteria, which included a new diagnosis of colorectal cancer, no prior therapy, and a total bilirubin of ≥3.0 mg/dL. All 20 ...

GEREÇ VE YÖNTEM Bu ileriye dönük, deneysel ve plasebo kontrollü çal›flma Akdeniz Üniversitesi hayvan laboratuvar›nda gerçeklefltirildi. %45’lik N H O3 ile %18’lik H C l plasebo ile karfl›laflt›r›ld›. Solüsyonlar her biri 10 s›çandan oluflan 3 gruba a¤›zdan verildi. Solüsyonlar verilmeden önceki ve sonraki pH ve kalsiyum de¤erleri ölçülerek, meydana gelen metabolik de¤ifliklikler izlendi. Ayr›ca...

Sarcoidosis is a systemic inflammatory disease characterized by the development of noncaseating granulomas in multiple organ systems. Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-year-old man with melanoma-associated sarcoidosis. In addition, we not only review the literature d...

Chronic groin pain in athletes is a difficult diagnostic and therapeutic condition. Between March 2004 and December 2009, 241 male athletes (mean age: 25.8 years, range: 16-41) in whom chronic sportsman's hernia was diagnosed, were surgically treated using a standardised technique. In this retrospective study, charts were analyzed for preoperative duration of symptoms and prior treatment. Perio...