gamma-Aminobutyric acid (GABA)A receptor-mediated inhibitory synaptic transmission in visual cortex undergoes long-term potentiation (LTP), which is input-specific and associative. The present study, conducted under a blockade of ionotropic glutamate receptors, demonstrates an induction mechanism of LTP considerably different from those of associative LTP at excitatory synapses. Inhibitory resp...

We investigated the effects of intrathecal application of GABAA- or GABAB-receptor agonists on detrusor-sphincter dyssynergia (DSD) in spinal cord transection (SCT) rats. Adult female Sprague-Dawley rats were used. At 4 wk after Th9-10 SCT, simultaneous recordings of intravesical pressure and urethral pressure were performed under an awake condition to examine the effect of intrathecal applicat...

Though we are approaching the end of second wave COVID pandemic, still unrevealing various presentation this viral infection can result in. There few cases reported to have anti NMDA autoimmune encephalitis associated with COVID-19 or MIS-C. Here reporting one its variants that was anti-GABAB receptor infection. We a 9 years old female child who known case seizure disorder and on regular medica...

This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i...

Introduction: The Bed nucleus stria terminalis (BST) is a part of the limbic system. It was recently shown that chemical stimulation of the BST by L-glutamate elicited cardiovascular depressive responses. In the present study, we have investigated the possible cardiovascular role of the GABAergic receptors in BST by microinjection of its agonist and antagonists. Methods: Experiments were p...

bstract—Although multiple effects of GABAB receptor actiation on synaptic transmission in the striatum have been escribed, the precise locations of the receptors mediating hese effects have not been determined. To address this ssue, we carried out pre-embedding immunogold electron icroscopy in the rat using antibodies against the GABAB eceptor subunits, GABAB1 and GABAB2. In addition, to inesti...

introduction: the bed nucleus stria terminalis (bst) is a part of the limbic system. it was recently shown that chemical stimulation of the bst by l-glutamate elicited cardiovascular depressive responses. in the present study, we have investigated the possible cardiovascular role of the gabaergic receptors in bst by microinjection of its agonist and antagonists. methods: experiments were perfor...

The effect of partial hippocampal kindling, a model of temporal lobe seizure, on monosynaptic inhibition mediated by GABA was studied. Kindled rats were given 15 nonconvulsive hippocampal afterdischarges, and control rats were given low frequency or no stimulations. At 1-2 d after kindling, paired-pulse depression (PPD) of the IPSCs recorded in CA1 neurons in vitro was significantly smaller in ...