BACKGROUND AND PURPOSE Many stroke trials have provided neutral results. Suboptimal statistical analyses may be failing to detect effective interventions. Adjusting outcomes for baseline prognostic factors in the analysis may improve the efficiency of analysis of outcomes. METHODS Data from 23 stroke trials (25 674 patients) assessing functional outcome were included. The prognostic variables...

Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.

Trans-acting small interfering RNAs (siRNAs) trigger a digital silencing response in Paf1C mutant fission yeast cells. Shown here are individual fission yeast colonies that present two different phenotypes (white or red), although all cells are genetically identical. Cells turn red upon siRNA-directed assembly of heterochromatin at the ade6+ gene. Variegating colonies indicate that descendants ...

As experience is gained in the attempt to apply counter-current distribution to the separation of complicated biological substances from the mixtures in which they naturally occur, it becomes abundantly clear that the solubility and the hydrophobic or hydrophilic properties of known pure components are markedly altered in such mixtures. Thus, one solute may carry with it into solution a second ...

Intuitive interaction involves utilising knowledge gained through other products or experience(s). Therefore, products that people use intuitively are those with features they have encountered before. This position has been supported by experimental studies. The findings suggest that relevant past experience is transferable between products, and probably also between contexts, and performance i...

Formin proteins are key regulators of the cytoskeleton involved in developmental and homeostatic programs, and human disease. For these reasons, small molecules interfering with Formins' activity have gained increasing attention. Among them, small molecule inhibitor of Formin Homology 2 domains (SMIFH2) is often used as a pharmacological Formin blocker. Although SMIFH2 inhibits actin polymeriza...

Plasma angiotensin concentrations were measured in a longitudinal study of the vascular, renal, and adrenal responses to infusions of angiotensin II (AII) in the maturing newborn lamb. Basal plasma concentrations of angiotensin increased with age and correlated with the rising arterial pressure that occurred with maturation. However, age was a stronger determinant of arterial pressure than was ...

background: coccidiosis of domestic fowl, caused by species of the genus eimeria , is responsi­ble for important economic losses in poultry production. because different species and/or strains can vary in pathogenicity and other biological parameters, their precise characteriza­tion is important for epizootiological studies. methods: fifty samples from litter, whole intestinal tract and feces w...