Functional gallbladder disorder is a motility disorder of the gallbladder that results in decreased gallbladder contractility and colicky pain. The term is used to cover a constellation of symptoms that have led to their codification in the Rome III criteria (Table 1).1 Previously, functional gallbladder disorder was called chronic acalculous cholecystitis, acalculous cholecystitis, biliary dys...

OBJECTIVE To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces of China (Shaanxi Province, Gansu Province, Qinghai Province, Ningxia Hui Autonomous Region, and Xinjiang Uygur Autonomous Region) from 2009 to 2013, and to summarize the clinical diagnosis and treatment data of gallbladder carcinoma...

patients with a covered metallic stent (CMS) placed in the bile duct [1,2]. Percutaneous transhepatic gallbladder drainage, which involves an external drainage tube, decreases the ability of the patient to carry out their normal daily activities. Recently, endoscopic ultrasound (EUS)guided drainage has been employed successfully for hepatogastrostomy, bilioduodenostomy, and pancreatogastrostomy...

UNLABELLED This study investigated the use of a corn oil emulsion as an inexpensive alternative to sincalide in the scintigraphic diagnosis of chronic acalculous cholecystitis (CAC). METHODS Thirty patients with abdominal or right upper quadrant pain underwent (99m)Tc-disofenin hepatobiliary imaging for 60 min. After gallbladder filling, 30 mL of corn oil emulsion were administered orally to ...

Muscarinic receptors play a major role in gallbladder function, although the muscarinic receptor(s) mediating smooth muscle contractility is unclear. This study compared smooth muscle contractile responses to carbamylcholine (10(-7)-10(-3) M) in isolated gallbladder from wild-type and M(2), M(3), and M(4) receptor knockout mice. Carbamylcholine-induced contraction in gallbladder was associated ...

PSCA and Oct-4 have been thought as markers of cancer stem cells. Although overexpression of PSCA and Oct-4 in cancer has been reported, little is known about the clinical and pathological significance with PSCA and Oct-4 expression in gallbladder adenocarcinoma. In this study, overexpression of PSCA and Oct-4 was detected in gallbladder adenocarcinoma (54.6% and 55.6%). Less expression of PSCA...

The aim of this study was to develop a pilot model for the assessment of the severity of gallbladder diseases based on gallbladder contraction index, clinical and sonographic appearances of the gallbladder. The gallbladder contraction index (GBCI) was obtained as the average of the first ten and the first 20 minutes contraction indices. A range of 5% to 77% previously obtained in normal subject...

Gallbladder cancer represents the most common malignancy of the biliary tract and is highly lethal with less than 5% overall 5-year survival rate. Chemotherapy remains the major treatment for late-stage patients. However, insensitivity to these chemotherapeutic agents including cisplatin is common. MicroRNAs (miRNAs) have been shown as modulators of drug resistance in many cancer types. We used...

Introduction Cholecystectomy is the surgical removal of gallbladder for symptomatic gallstones disease or where exist the risk of gallbladder malignancy. Its performed routinely across the globe often as day surgery. In this case report, we describe an incidental intra operative finding of a left sided gallbladder creating a technical challenge for the surgeon. Case We describe the case of 35...

The main cause of perforation of the gallbladder is cholecystitis with or without cholelithiasis. In old age, spontaneous perforation of gallbladder can be due to decrease in its blood supply, which can be due to atherosclerosis, focal vasospasm or localized vasculitis. Perforation of gallbladder is associated with high morbidity and mortality, if left untreated. Here we report a case of a 60-y...