gamma-Glutamyltransferase is widely used as a marker of alcohol intake although its performance is poor. This might be related to other conditions influencing gamma-glutamyltransferase activity. The authors studied determinants of gamma-glutamyltransferase activity in a random sample (n = 6,010) drawn from the general population aged 25-64 years in Finland in 1992. In regression analysis, coffe...

in many manufacturing processes, the quality of a product is characterized by a non-linear relationship between a dependent variable and one or more independent variables. using nonlinear regression for monitoring nonlinear profiles have been proposed in the literature of profile monitoring which is faced with two problems 1) the distribution of regression coefficients in small samples is unkno...

BACKGROUND AND PURPOSE Gamma knife radiosurgery has become an important treatment option for vestibular schwannoma. The effect of treatment can be assessed only by neuroimaging. We analyzed the evolution of follow-up MR imaging findings after gamma knife radiosurgery to provide information for the clinical management of these tumors. METHODS Changes in tumor volume and enhancement were assess...

Using regression analysis to make inference using data sets that contain a large number of potentially correlated covariates can be difficult. This large number of covariates have become more common in clinical observational studies due to the dramatic improvement in information capturing technology for clinical databases. For instance, in disease diagnosis and treatment, obtaining a number of ...

Dark matter annihilation has been proposed to explain the TeV gamma rays observed from the Galactic Center. We study constraints on this hypothesis coming from the mass profile around the Galactic Center measured by observing stellar dynamics. We show that for several proposed WIMP candidates, the constraints on the dark matter density profile from measurements of mass by infrared observations ...

The Fermi Gamma-ray Space Telescope has revolutionized our knowledge of the gamma-ray pulsar population, leading to the discovery of almost 100 gamma-ray pulsars and dozens of gamma-ray millisecond pulsars (MSPs). Although the outer-gap model predicts different sites of emission for the radio and gamma-ray pulsars, until now all of the known gamma-ray MSPs have been visible in the radio. Here w...

We have recently shown that effector T cells (T(E)) lacking either perforin or IFN-gamma are highly effective mediators of tumor regression. To rule out compensation by either mechanism, T(E) deficient in both perforin and IFN-gamma (perforin knockout (PKO)/IFN-gamma knockout (GKO)) were generated. The adoptive transfer of PKO/GKO T(E) mediated complete tumor regression and cured wild-type anim...

Abstract— In some real case problems, a relationship between a response variable and one or more explanatory variables called as profile is desirable to be monitored over time instead of the response variable itself. There are many techniques in the literature for monitoring the profiles. A special case of the profiles is where the response variable follows a binomial distribution known as Logi...

BACKGROUND Psychologic stress modifies immune function and cytokine production. OBJECTIVE We examined relationships between caregiver stress on the following markers of early childhood immune response: (1) IgE expression (n=215); (2) mitogen-induced and allergen-specific (Dermatophagoides farinae [Der f 1] and cockroach [Bla g 2]) proliferative response (n=114); and (3) subsequent cytokine ex...

Semiquantitative reverse transcription-PCR assays were developed to measure feline interleukin-2 (IL-2), IL-4, IL-5, IL-6, IL-10, and IL-12 (p35 & p40); gamma interferon (IFN-gamma); and glyceraldehyde-3-phosphate dehydrogenase mRNA concentrations in biopsies of feline oral mucosa. Biopsies were collected from 30 cats with chronic gingivostomatitis (diseased) prior to each cat receiving one of ...