Solitary pulmonary nodule (SPN or coin lesion) is a mass in the lung and can be commonly found in chest X-rays or computerized tomography (CT) scans. However, despite the advancement of imaging technologies, it is still difficult to distinguish malignant cancer from benign SPNs. Here we investigated the metabolic profiling of patients with benign and malignant pulmonary nodules. A combination o...

The essential oil from the seeds of Cuminum cyminum L. was isolated by hydrodistillation method and the chemical composition was determined by gas chromatography-mass spectrometry (GC/MS). The yield of the oil was found to be 3.0% (on dry weight basis). A total of twenty six components, representing 96.7% of the oil were identified. Cuminaldehyde (49.4%), p-cymene (17.4%), b-pinene (6.3%), a-ter...

The analysis and characterization of 12 “designer” tryptamines by electrospray ionization mass spectrometry (ESI-MS) are presented. Molecular weights were confirmed based on the experimental observation of protonated and deprotonated pseudo-molecular ions in the positive and negative ion modes, respectively. Standard tandem mass spectrometry (MS) experiments were also performed, and the results...

Smoking marijuana during pregnancy can cause health problems in the neonate. The detection of exposure can guide treatment to meet the short- and long-term medical and social needs. Umbilical cord tissue was analyzed for 11-nor-delta-9-carboxy-tetrahydrocannabinol (THC-COOH) by gas chromatography-mass spectrometry (GC-MS), and compared with ultra-sensitive enzyme-linked immunosorbent assay (ELI...

In the medical examiner setting, comprehensive drug screening is an essential analytical tool in the investigation of cause and manner of death.We have validated non-targeted and targeted screening assays for drugs and metabolites using ultra-performance liquid chromatography (UPLC) interfaced with mass spectrometry (MS) in single and tandem stages. For non-targeted screening by UPLC-MS electro...

Abderaz The composition of the essential oil obtained from the seeds of Ammi majus L. which collected from province of Khozestan in the southwest area of Iran.The oils was analyzed by gas chromatography mass spectrometry (GC-MS). Twenty - eight components have been identified in the extract of A. majus L. with Toluene (3.766%), Thymol (12.811%), Carvacrol (37.811%) as major components, respecti...

Fast and reliable analytical methods for mercury speciation would aid in understanding mercury offgas chemistry. Presently, the U.S. Environmental Protection Agency (EPA) regulates only total mercury; however, many studies indicate that mercury toxicity is highly dependent on the mercury speciation. For example, amalgams and mercury sulfides have relatively low toxicities, while organomercury a...

Objective: Vitex agnus-castus (VAC) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. In this study, the effects of essential oil extracted from Vitex agnus-castus (EOVAC) leaves were investigated in three behavioral models of nociception in adult male Wistar rats. Materi...

OBJECTIVE To develop an analytical method for simultaneously qualitative and quantitative determination of melamine and triazine-related by-products including ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry (GC-MS/MS). METHODS Melamine and triazine-related by-products namely ammelide, ammeline and cyanuric acid in the samples were...

Mass spectrometry coupled to gas chromatography (GC-MS) has been widely applied in the field of metabolomics. Success of this application has benefited greatly from computational workflows that process the complex raw mass spectrometry data and extract the qualitative and quantitative information of metabolites. Among the computational algorithms within a workflow, deconvolution is critical sin...