Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors' genetic profiling using new breakthrough technolo...

BACKGROUND This study was aimed at comparing the safety of bisphosphonates in women with osteoporosis by application of equivalence testing. METHODS Gastrointestinal and renal side effects were evaluated based on information published in randomized controlled trials. RESULTS The data on gastrointestinal side effects (47 trials) indicated that alendronate, risedronate etidronate, and zolendr...

Despite progress in the management of gastrointestinal malignancies, these diseases remain devastating maladies. Conventional treatment with chemotherapy and radiation is still only partially effective and highly toxic. In the era of increasing knowledge of the molecular biology of tumors and the interaction between the tumor and immune system, the development of targeted agents, including canc...

It is commonly believed that intestinal function déclines significantly with increasing âge. Elderly people express gastrointestinal complaints more frequently than younger people and some disorders (e.g., diverticulosis, ischémie bowel disease) occur primarily in the elderly. In addition, most elderly people take médications, and many of thèse agents hâve significant effects on gastrointestina...

Sarcoidosis is a multisystem disease of unknown origin that may affect every organ in the body. The non-caseating granuloma is the histologic hallmark of this disease; the granulomatous reaction occurs as a defensive response against a persistent antigen in a susceptible host. Different antigenic agents for sarcoidosis have been proposed, such as infectious pathogens and/or environmental factor...

Agents that modify serotonergic function have therapeutic potential for the treatment of visceral hypersensitivity, either through a direct effect on perception or through modulation of visceral tone or motility. Administration of selective serotonin reuptake inhibitors reduces oesophageal sensitivity to distension but not gastric sensitivity to distension. 5-HT ligands may also influence gastr...

For clarification of the nature of the side effects of macrolide antibiotics on the gastrointestinal tract, the motor-stimulating activity of these agents was studied in unanesthetized dogs. The results showed that erythromycin and oleandomycin, the 14-membered macrolides with two side chain sugars combined at C3 and C5 in a glycosidic linkage in parallel, strongly stimulate gastrointestinal mo...

Henoch–Schönlein purpura (HSP) is a systemic small vessel vasculitis, characterized by the deposition of immune complexes, mainly polymeric IgA1 and C3, in the skin, gastrointestinal tract, joints, and kidneys w1x. Although the aetiology remains unknown, HSP is often associated with infectious agents. All ages may be affected although it is more common in children, and has a male predominance. ...

Sphingolipids in digestive system are responsible for numerous important physiological and pathological processes. In the membrane of gut epithelial cells, sphingolipids provide structural integrity, regulate absorption of some nutrients, and act as receptors for many microbial antigens and their toxins. Moreover, bioactive sphingolipids such as ceramide or sphingosine-1-phosphate regulate cell...

chronic granulomatous disease (cgd) represents a group of inherited disorders of phagocytic system, manifesting recurrent infections at different sites. the present study was accomplished in order to determine the gastrointestinal manifestations of cgd patients. fifty-seven patients (38 males and 19 females) with cgd, who had been referred to three immunodeficiency referral centers in iran, wer...