In an autoimmune disease, the immune system attacks and harms the body's own tissues. The systemic autoimmune diseases include collagen vascular diseases, the systemic vasculitides, Wegener granulomatosis, and Churg-Strauss syndrome. These disorders can involve any part of the gastrointestinal tract, hepatobiliary system and pancreas. They can cause a variety of gastrointestinal manifestations ...

Eosinophilic gastrointestinal disorders (EGIDs) are a progressively more frequent diverse group of intestinal diseases. The intention of this paper is to present the newest developments in the care of patients with EGIDs and to sum up a rising literature defining the clinical features and mechanistic elements of eosinophils and their intricate associations with the gastrointestinal tract. Clini...

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Shaman Rajindrajith, MD Department of Pediatrics, Faculty of Medicine, ...

Innate immune cells - and many other cells - express evolutionarily conserved, germline-encoded receptors that recognize seemingly pathogen-derived ligands (also termed pathogen-associated molecular patterns), thereby allowing the host to perceive infection. Although they were the first to be discovered, Toll-like receptors (TLRs) are not the only pattern recognition receptors. TLRs are unlikel...

In recent years, novel flexible endoscopic approaches in the treatment of refractory intractable gastrointestinal diseases as well as established gastrointestinal diseases have evolved noticeably. The role of endoscopy is to diagnose and treat gastrointestinal diseases including cancer. However, recent developments and advances in flexible endoscopy enable the treatment of unresolved gastrointe...

Curcumin, also known as diferuloylmethane, is derived from the plant Curcuma longa and is the active ingredient of the spice turmeric. The therapeutic activities of curcumin for a wide variety of diseases such as diabetes, allergies, arthritis and other chronic and inflammatory diseases have been known for a long time. More recently, curcumin's therapeutic potential for preventing and treating ...

This paper reviews the composition of colostrum and the potential preventive and therapeutic use of this "first milk" for treating various gastrointestinal disorders in humans. Colostrum is a complex biological liquid that is richer in antimicrobial peptides, immune-regulating compounds and growth factors than the subsequent mature milk. The main functions of colostrum are to provide essential ...

BACKGROUND Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. METHODS We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. ...

Diverticular disease Angiodysplasia Adenomatous polyps Carcinoma Ischaemic colitis Inflammatory bowel disease Radiation proctitis Bleeding from the lower gastrointestinal tract is a common clinical problem in both general and hospital practice. Patients are alarmed when they pass blood, but most have minor anorectal disorders thait can be investigated and treated on an outpatient or day case ba...

Most inflammatory, neoplastic and vascular disorders manifest bowel wall thickening on computed tomography (CT). Therefore, it is very important to understand the patterns of bowel wall involvement (degree, length, symmetry and contrast enhancement patterns) in each category to make a correct diagnosis. Observing extraluminal changes also help to classify the primary causes of pathological cond...