The castration-induced atrophy of the rat prostate was used as a model for the validation of a sensitive technique allowing the quantitation of total mRNA in polyribosomes. Electron micrographs of polyribosome samples showed a decrease in polyribosomes length 7 days after castration (GDX). Specificity of labeled oligo(dt) probe for poly(A) was demonstrated and the technique was successfully app...

The exponential rise of sharing economy has accelerated the growth shared healthcare platforms in recent times. Although a platform transforms exchange service offerings, insight remains elusive regarding its value co-creation (VCC) dynamics and their effects. Drawing on DART (dialogue, access, risk assessment, transparency) framework, this study frames overall effects VCC perceived innovation,...

Context. Numerical simulations predict the existence of old Tidal Dwarf Galaxies (TDGs) that would have survived several Gyr after the collision lying at their origin. Such survivors, which would by now have become independent relaxed galaxies, would be ideal laboratories, if nearby enough, to tackle a number of topical issues, including the distribution of Dark Matter in and around galaxies. H...

The potential effects of monotypic and binary metal oxide nanoparticles (NPs, ZnO, NiO, Co₃O₄ and TiO₂) on microbial growth were evaluated in sandy soil collected from artificial recharge sites. Microbial growth was assessed based on adenosine triphosphate (ATP) content, dehydrogenase activity (DHA), and viable cell counts (VCC). Microbial growth based on ATP content and VCC showed considerable...

This paper identifies the practical requirements for building a successful KM implementation process. We propose Value Creation Cycle (VCC) as an integrative framework of KM implementation. The VCC framework includes four stages: Defining KM Value Proposition, Developing KM Infrastructure, Enabling Learning, and Assessing Value. The temporal relationship between these stages addresses two criti...

The Voice Conversion Challenge (VCC) 2016, one of the special sessions at Interspeech 2016, deals with the well-known task of speaker identity conversion, referred as Voice Conversion (VC). The objective of the VCC is to compare various VC techniques on identical training and evaluation speech data. The full description of VCC 2016, the motivation, the database, the rules, the participants and ...

The neural capacity (NC) of high-pass resolution perimetry (HRP) was compared to the retinal nerve fiber layer thickness measured with the GDx Nerve Fiber Analyzer in 74 patients with either ocular hypertension or primary open-angle glaucoma at various stages of severity. A statistically significant correlation was found between the NC and the GDx ellipse average, the total polar integral, and ...

In order to characterize the action of androgen in skeletal muscle, we have investigated the effects of castration (GDX) and dihydrotestosterone (DHT) on global gene expression in mice. The serial analysis of gene expression method was performed in the muscle of male mice in six experimental groups: intact, GDX and GDX+DHT injection 1, 3, 6 or 24 h before they were killed. A total of 780 822 se...

Alcohol (EtOH) can enhance aggression in people and animal models. These effects are more salient in males than in females. Androgens, such as testosterone (T), may promote aggressive responding to EtOH. Effects of EtOH on androgens and aggression were examined in a resident-intruder paradigm. Gonadally-intact, or castrated (GDX), male rats were socially-isolated for 3 weeks and administered an...

Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing hormone (GnRH) system in the hypothalamus of male rats. Also, we assessed the expression of two excitatory (kisspeptin and...