BACKGROUND Gemcitabine (GEM) is the most widely utilized systemic agent in combination with radiation therapy (RT) for treating locally advanced pancreatic cancer (LAPC) in the concurrent setting. Despite recent interest in using two novel oral fluoropyrimidines (FUs), capecitabine and S-1, in this setting, there is a lack of randomized controlled trials (RCTs) to support this approach. METHO...

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

p56/ok (Lck) is a lymphoid-specific Src family tyrosine kinase that is critical for T-cell development and activation. Lck is also a membrane protein, and approximately half of the membrane-associated Lck is associated with a glycolipid-enriched membrane (GEM) fraction that is resistant to solubilization by Triton X-100 (TX-100). To compare the membrane-associated Lck present in the GEM and TX-...

BACKGROUND Nanoparticle albumin-bound paclitaxel (nab-P) plus gemcitabine (Gem) became a standard treatment option for metastatic pancreatic cancer (MPC) following positive results from a global phase III trial (MPACT). A large number of studies have now published results on the use of nab-P/Gem to treat advanced and early-stage disease, warranting a comprehensive review. The main goal of this ...

To improve natural killer group 2 member D (NKG2D)-dependent cytotoxicity, the inhibition of cleavage and release of major histocompatibility complex class 1-related chain (MIC) molecules from the tumor surface are required. Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is able to induce cell-surface MICA/B on tumor cells. In the present study, the ability of VPA and gemcitabine ...

PURPOSE To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM-progression of patterns (POP) and VIM-POP). To compare GEM-POP and VIM-POP with other methods. METHODS GEM and VIM models separated cross-sectional abnorma...

Southern Indian states are endowed with rich gem mineral wealth. High potential region for the occurrence of gem deposits appear to be the Precambrian region in the Eastern Ghats. Gemstones which are of mineral origin are found largely in metamorphic terrain. Salem district which is primarily enclosed by high grade metamorphic rocks is the study area. This study addresses field investigation an...

Ann Surg Oncol. 2007 Dec;14(12):3620-8. Inhibition of proliferation by omega-3 fatty acids in chemoresistant pancreatic cancer cells. Hering J, Garrean S, Dekoj TR, Razzak A, Saied A, Trevino J, Babcock TA, Espat NJ. Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, USA. BACKGROUND: Pancreatic cancer-gemcitabine (GEM) chemoresistance has been demonstrated to be associ...

1 Abstract The GEM compiler system is the technology Digital is using to build state-of-the-art compiler products for a variety of languages and hardware /software platforms. Portable, modular software components with carefully specified interfaces simplify the engineering of diverse compilers. A single optimizer, independent of the language and the target platform, transforms the intermediate ...