The auricularia larva of sea cucumbers and tornaria larva of acorn worms share striking developmental and morphological similarities. They are regarded as not only an archetype of the nonchordate deuterostome larva, but also an archetype of the origin of chordates. Here we report the characterization and spatial expression patterns of the BMP-2/4 genes of a hemichordate acorn worm (Pf-bmp2/4) a...

Social media in general and wikis in particular offer unique opportunities for knowledge management. Despite widely publicised successes in public settings, wikis in businesses evince mixed results; enterprises struggle to apply wikis to institutionalise knowledgemanagement practices. We investigate the inherent tensions underlying knowledge-sharing in competitive and hierarchical organisations...

The objective of this study is to investigate the implications for organisational performance of the interplay between ownership and management control system design in professional service organisations. Based on transaction cost economic (TCE) theory, we expect that low ownership by professionals working in a professional services organisation will be more efficiently managed with a boundary ...

Organizational change has been explained according to a variety of perspectives. One approach, the holistic view of organizational development, suggests organizations gravitate towards coherent configurations or “archetypes”. While archetype theory provides a conceptually astute frame in which to examine revolutionary change, it is criticized for emphasizing deterministic, or institutional as o...

Viral microRNAs (miRNAs) play an important role during infection by posttranscriptionally regulating both host and viral gene expression. However, the function of many viral miRNAs remains poorly understood. In this study, we investigated the role of the BK polyomavirus (BKPyV) miRNA in regulating virus replication. The function of the polyomavirus miRNA was investigated in archetype BKPyV, whi...

The problem of detecting outliers in multivariate data sets with continuous numerical features is addressed by a new method. This method combines projections into relevant subspaces archetype analysis nearest neighbor algorithm, through an appropriate ensemble the results. Our able to detect anomaly simple set linear correlation two features, while other methods fail recognize that anomaly. per...