genetic epidemiological studies strongly suggest that additive and interactive genes, each with small effects, mediate the genetic vulnerability for schizophrenia. with the human genome working draft at hand, candidate gene (and ultimately large-scale genome-wide) association studies are gaining renewed interest in the effort to unravel the complex genetics of schizophrenia. linkage and fine ma...

conclusions this is the first report of expression of cmv cp gene in iran, which is important for the preparation of anti-cmv antibody and paving the way for the use of the virus coat protein as a nanomaterial. results the identity of the expressed protein was confirmed by immunoassays such as western blot, dot-immunobinding assay (diba) and enzyme-linked immunosorbent assay (elisa) by the use ...

background: zinc (zn) as an important trace element is essential for testicular development and spermatogenesis. molecular mechanism of zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (mt). our objective was to determine the effect of zn on two important isoforms of mt, mt1m and mt1g genes expression on testicular sertoli cell...

objective(s):  apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (sle), in present study we studied the apoptosis in t lymphocytes from iranian sle patientsat protein and gene expression levels for some molecules which are involved in apopt...

extracellular ca 2+ concentration ([ca2+]o) may be one of the factors affecting atrial natriuretic factor (anf) release. in the previous studies, there are opposite reports about the effect of [ca2+]o on anf secretion. therefore, the effect of [ca2+]o depletion on anf secretion and gene expression was studied in the present research. isolated right atria from rats were perfused for 6 and 2 hour...

Objective: Physical exercise has different effects on oxidative stress. Oxidative stress influences TLR4 and NFkB gene expression. The purpose of this study was to investigate the effect of aerobic training and vitamin D on gene expression of TLR4 and NFkB in lung tissue of obese rats exposed to oxygenated water. Materials and Methods: In an experimental study, 30 obese male wistar rats were r...

Background Sertoli cells located in seminiferous tubular basement membrane and surrounds different types of germ cell and they were only somatic cell type that directly contacts germ cells. These cells have Several role like support activities, nutrition of germ cells.During spermatogenesis, expression of SOX3 is necessary for differentiation of spermatogonia A. SOX3 is a transcription factor, ...

Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the susceptibility to H. pylori or the disease outcomes. But the details and association to different polymorphis...