background: germ-line mutations of brca1 and brca2 genes are responsible for approximately 25-30% of dominantly inherited familial breast cancers; still a big part of genetic component is unknown. the aim of this study was to investigate genetic causes of familial breast cancer in a pedigree with recessive pattern of inheritance. methods: we applied exome sequencing as a useful approach in hete...

Abstract In order to protect non-genetic inheritance, this paper proposes the construction of digital platform for inheritance based on PEST-SWOT model. Firstly, classification intangible Chinese heritage is summarized and development Jiaodong dough plastic cultural analyzed by using SWOT PEST analysis Finally, strategy protection constructed, information collected classified data collection ar...

Focal facial dermal dysplasias (FFDDs) are rare genetic/developmental disorders characterised by bilateral 'scar-like' facial lesions. Four subtypes are classified by the bitemporal (FFDD1-3) or preauricular (FFDD4) lesion location. FFDD1-3 are differentiated by additional facial abnormalities and inheritance patterns. Although the genetic defects causing FFDD1 and FFDD2 remain unknown, recent ...

Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases with genetic and clinical heterogeneity characterized by spasticity weakness the lower limbs. It includes four inheritance forms: autosomal dominant (AD), recessive (AR), X-linked inheritance, mitochondrial inheritance. To date, more than 82 gene loci have been found to cause HSP, SPG15 ( ZFYVE26 ) one most common here...

Ejaculate size in seed beetles (Coleoptera: Bruchidae) is subject to both sexual and fecundity selection. We examined interpopulation variation and inheritance of ejaculate size in the seed beetle Callosobruchus maculatus (F.). There was signiÞcant variation among three populations in both body mass and the proportion of a maleÕs body mass that was transferred to females during mating. The seed...

We present a general model for the effect of sex linkage on the evolution of reinforcement of mating preferences on an island. We find that the level of reinforcement can vary up to 80% depending on the mode of inheritance of the female preference and male trait. When reinforcement is driven mainly by selection in the male trait and intrinsic hybrid incompatibilities are weak, sex-linked prefer...

The major aim of this study is to determine the mode of inheritance of asymmetry of quantitative dermatoglyphic traits based on principal factors through the application of complex segregation (genetic model fitting) analyses on a large ethnically homogeneous sample of 500 Indian pedigrees (2435 individuals) of two generations. By segregation analysis of the traits- PC1_FA both Mendelian and En...

Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absence of any simple Mendelian pattern of inheritance: in place of the hypothesis t...

BACKGROUND The biological justification for the choice of the genetic mode in genetic association studies (GAS) is seldom available. Then, the mode of inheritance is approximated by investigating a number of non-orthogonal genetic contrasts making the interpretation of results difficult. METHODS We propose to define the mode of inheritance by the significance of the deviance of the co-dominan...