Glioblastoma multiforme is one of the most common and malignant types central nervous system (CNS) tumors. Despite great advances in treatment modalities variety therapeutic options, it remains largely incurable with continuously growth incidence, due to genomic instability glioblastoma cells, their heterogeneity, resistance chemo- radiotherapies. The aggressive behavior these brain tumors sequ...

The interindividual variability of Proton Pump Inhibitor (PPI) therapy results from the phenotype associated with cytochrome P450 2C19 (CYP2C19) gene, namely CYP2C19*17 allele. Our aim was to characterize patients’ genetic undergoing PPI therapy. A sample 33 oral mucosa cells Portuguese pharmacy patients collected, followed by genotyping. allelic frequencies CYP2C19*1 (-806C) and (-806T) were 7...