Twelve replications of four littermate pigs from a herd naive for porcine reproductive and respiratory syndrome (PRRS) were weaned (10 ± 2 d of age) and penned individually in disease isolation rooms. Pigs were randomly allotted within litter to one of four dietary concentrations of soy genistein (0, 200, 400, 800 ppm) to quantify the effect of genistein on growth and immune response during a v...

Background: Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of nephrotic syndrome. L-carnitine and genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine production. This study was designed to examine the effects of genistein and L-carnitine on ...

Background: An estimated six percent of adult males are thought to be infertile. The opioid peptides, in particular enkephalins, are implicated in pain perception, in response to stress, and in reinforcement. Many studies have been performed on morphine and its deleterious effects on different parts of the body and reproductive system of animals and human. Soybean, widely used in animal and hum...

Genistein, the predominant isoflavone found in soy products, has exerted its anticarcinogenic effect in many different tumor types in vitro and in vivo. Accumulating evidence in recent years has strongly indicated the existence of cancer stem cells in gastric cancer. Here, we showed that low doses of genistein (15 µM), extracted from Millettia nitida Benth var hirsutissima Z Wei, inhibit tumor ...

Objective: The aim of this study was to investigate the antibacterial activity of Genistein and Quercetin against pathogens of the urinary tract infection (UTI). Methods: An in vitro study was carried out using the following bacterial strains involved in UTI diseases using well diffusion (WD) testing: Escherichia coli (ATCC 25922) and 10 strains were compiled from Aleppo Hospital. It was from w...

This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses...

introduction: estrogen is one of the female sex hormones that in addition to its reproductive role, has favorable fects on the metabolism of blood lipids and lipoproteins and by this way decreases the coronary heart disease. n the other hand, phytoestrogens are phytochemical substances that have effects like estrogens. isoflavones, hich the most important of them is genistein, are the most comm...

Twelve replications of four littermate pigs from a herd naive for porcine reproductive and respiratory syndrome (PRRS) were weaned (10 +/- 2 d of age) and penned individually in isolation rooms. Pigs were randomly allotted within litter to one of four dietary soy genistein concentrations (0, 200, 400, and 800 ppm) to quantify the effect of soy genistein on pig growth and virus replication durin...

Platelet-activating factor (PAF) is a proinflammatory lipid that has platelet-stimulating property. PAF receptor-coupled activation of phosphoinositide-specific phospholipase C (PLC) and phosphorylation of several proteins has already been established in our laboratory. To investigate further the molecular mechanism and relationship between activation of PLC and protein phosphorylation, we have...

Soy isoflavone genistein exhibits growth inhibitory activity against human pancreatic cancer cell lines. We previously reported the potential of genistein to augment chemotherapeutic response of pancreatic cancer cells in vitro. In the present study, we investigated whether genistein pretreatment could be used as a novel strategy for gemcitabine-induced killing in vitro and enhanced antitumor a...