We examined the effect of perinatal hypothyroidism on auditory function in rats using a prepulse inhibition paradigm. Pregnant rats were treated with the antithyroid drug methimazole (1-methyl-2-mercaptoimidazole) from gestational day 15 to postnatal day 21 via drinking water at concentrations (w/v) of 0 (control), 0.002 (low dose), or 0.02% (high dose). Rats from methimazole-treated mothers we...

There is a well-known controversy among scientific societies regarding the recommendation to screen for thyroid dysfunction (TD) during pregnancy. Although several studies have shown an association between maternal subclinical hypothyroidism and/or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, there is only limited evidence on the possible positive ...

Introduction: Pregnancy induced hypertension (PIH) is an important cause of maternal and fetal morbidity mortality affecting 5-10% pregnancies. PIH more frequently associated with elevated TSH (Thyroid-stimulating hormone). Thyroid dysfunction plays role in the development gestational hypertension. However, this relationship remains unclear. The study was performed to evaluate thyroid status pr...

The purpose of this study was to explore the impact maternal thyroid hormone dysfunction in late pregnancy on birth outcomes a Chinese population. We retrospectively examined hospitalisation records and laboratory data between April 2016 March 2017 obtained results from 11,564 consecutive pregnant women with singleton births which serum had been together outcomes. assessed association level adv...

In babies with congenital hypothyroidism, goiter and respiratory distress (due to upper airway compression/hypothyroidism) are rarely encountered as the first presenting signs. Computerized Tomography of neck revealed enlargement all thyroid gland lobes further laboratory hypothyroidism. Thyroid hormone replacement therapy was initiated early, which resulted in a significant reduction regressio...

Primary hypothyroidism is a graded phenomenon with a wide spectrum of severity between subclinical hypothyroidism and overt hypothyroidism. Patients with biochemically severe hypothyroidism may present with only mild clinical manifestations, whereas some patients with moderate changes in thyroid hormones may present with severe signs of tissue hypothyroidism. The measurement of pituitary thyroi...

Background: Evaluation of thyroid disorder in pregnancy is essential for maternal health, obstetrical outcome and neurodevelopment the child. Euthyroid pregnant women having positive peroxidase antibodies have an elevated risk miscarriage, premature birth, gestational hypertension, intrauterine fetal demise. Thyroid autoimmunity (TAI) subclinical hypothyroidism (SCH) been connected with adverse...

Objectives: Subclinical hypothyroidism has been defined as normal free thyroxine (FT4) with elevated thyroid stimulating hormone (TSH) levels. The aim of this study is to examine the relationship between first trimester subclinical adverse obstetric outcomes in pregnant women. Methods: This retrospective cohort was conducted by examining women who applied Gynecology Department Okmeydani Trainin...

TWO TRABS: TSBAb and TSAb. TSBAb causes hypothyroidism. TSAb causes Graves' hyperthyroidism. TSBAb and TSAb block TSH-binding to cells as TRAb, measured as TSH-binding inhibitory immunoglobulin (TBII). We reevaluate TSBAb and TSAb. We studied TSBAb, TSAb, and TBII over 10 years in 34 TSBAb-positives with hypothyroidism and in 98 TSAb-positives with hyperthyroidism. Half of the 34 TSBAb-positive...