Glioblastomas, the most malignant of all brain tumors, are characterized by cellular resistance to apoptosis and a highly invasive growth pattern. These factors contribute to the poor response of glioblastomas to radiochemotherapy and prevent their complete neurosurgical resection. However, the driving force behind the distinct motility of glioma cells is only partly understood. Here, we report...

abstract background: cholesterol cleft granulomas with clusters of giant cells were noted to be a common feature of non-specific interstitial pneumonia (nsip). objective: this study aimed to define the cell populations involved in the granulomas. methods: the granulomas of 16 patients with cryptogenic fibrosing alveolitis (five cases with the histological features ofnsip, five with those ofuip ...

five cases of giant cell tumor of the lower end of radius are reported. three of the patients were women and two were men, the youngest of the patients was 18 years old and oldest 37 years. en bloc resection followed by reconstructive procedures were performed in three of the cases with good results.

BACKGROUND AND PURPOSE Glioblastomas, brain metastases, and PCLs may have similar enhancement patterns on MR imaging, making the differential diagnosis difficult or even impossible. The purpose of this study was to determine whether a combination of DTI and DSC can assist in the differentiation of glioblastomas, solitary brain metastases, and PCLs. MATERIALS AND METHODS Twenty-six glioblastom...

The PTEN (MMAC1) gene, which has been identified as a tumor suppressor gene at 10q23.3, is mutated in multiple malignant tumors, including glioblastomas [J. Li et al., Science (Washington DC), 275: 1943-1947, 1997; P. A. Steck et al., Nat. Genet., 15: 356-362, 1997]. Among tumors of the central nervous system, loss of 10q is not restricted to glioblastomas but is also common in atypical and ana...

Presenting a very dismal prognosis, glioblastomas present as one of the most malignant brain tumors [1]. In addition to its low prognosis, glioblastomas account for ~70% of all astrocytic and oligodendroglial tumors, making this one of the most common types of brain tumors [1]. Through the mutations of multiple pro-oncogenic genes, primary glioblastomas develop as other neoplasms but present as...

giant cell granulomas of the jaws are rather common in [rail, however, more reliable data need to be published in this retrospecti ve study 1,083 cases ojpgco and cgcg (817 peripheral and 203 central) were extracted from 6800 oral biopsy archives of the oral pathology department and were analyzed: age and sex ofthe patients and type and location distribution were obtained our results show that ...

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Purpose: To establish the frequency of IDH1mutations in glioblastomas at a population level, and to assess whether they allow reliable discrimination between primary (de novo) glioblastomas and secondary glioblastomas that progressed from low-grade or anaplastic astrocytoma. Experimental Design: We screened glioblastomas from a population-based study for IDH1 mutations and correlated them with ...