Herb-drug interactions have received more attention in recent years because of the widespread popularity of herbal supplements. However, there are limited data on the effect of herbs on glucuronidation in humans. The goal of this work was to examine the effect of Ginkgo biloba extract and its main flavonoid and terpene lactone constituents on mycophenolic acid (MPA) 7-O-glucuronidation. Human l...

Ginkgolic acids (GA) have been reported to exhibit anticancer properties, however, 15 the mechanisms remain unclear. This study aims to investigate the mechanisms of GA C13:0 16 that was isolated from Ginkgo biloba exocarp (GBE) for anti-proliferation, pro-apoptosis and 17 anti-migration effects in human MCF-7 and mouse 4T-1 breast cancer cells. The cytotoxic 18 effect, apoptosis induction and ...

objective: exposure to traumatic stressors lead to activation of arousal responses mediated by serotonergic and noradrenergic systems and it may cause a change in numerous neurotransmitters and neuroendocrine systems. there is ample experimental and clinical evidence to suggest that ginkgo biloba extract is neuroprotective and has antioxidant properties and can restore stress-induced elevation ...

the entomopathogenic fungus beauveria bassiana (bals.) vuill. is one of the important arthropod pathogens that can play an important role in the regulation of mite populations in agricultural ecosystems. in this study, the combined effect of a native isolate of fungus b. bassiana (eut105) and ether-extract of plant, ginkgo biloba was evaluated against the two-spotted spider mite, tetranychus ur...

Many extracts prepared from plants traditionally used for medicinal applications contain a variety of phytochemicals with antioxidant and antigenotoxic activity. In this work we measured the DNA protective effect of extracts of Ginkgo biloba leaves from oxidative stress using Saccharomyces cerevisiae as experimental model. The extract improved viability of yeast cells under oxidative stress imp...

Vellas B, Coley N, Ousset PJ, et al; GuidAge Study Group. Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimers disease (GuidAge): a randomised placebo-controlled trial. Question In elderly patients who report memory complaints to their primary care physicians, does ginkgo biloba extract reduce risk for Alzheimer disease (AD)? Methods Design: Randomized placebo-co...

The case of a 56 year old man who suffered a spontaneous intracerebral haemorrhage after regular self medication with the herbal preparation, Ginkgo biloba leaf extract is described, and the possible association is discussed.