PURPOSE The authors recently reported that a recombinant HSV-1 expressing two extra copies of glycoprotein K (gK) exacerbated corneal scarring (CS) in mice. The authors also identified a peptide, STVVLITAYGLVLVW, within the signal sequence of gK as an immunodominant gK T-cell-stimulatory region both in vitro and in vivo and identified a highly conserved potential CD8(+) T-cell epitope (ITAYGLVL...

The logic of knowledge and justified assumptions, also known as the logic of grounded knowledge (GK), was proposed by Lin and Shoham as a general logic for nonmonotonic reasoning. To date, it has been used to embed in it default logic (propositional case), autoepistemic logic, Turner’s logic of universal causation, and general logic programming under stable model semantics. Besides showing the ...

Let ∆ be a thick building of type Xn = Cn,Dn. Let also Gk be the Grassmannian of k-dimensional singular subspaces of the associated polar space Π (of rank n). We write Gk for the corresponding shadow space of type Xn,k. Every bijective transformation of Gk preserving the class of base subsets (the shadows of apartments) is a collineation of Gk, and it is induced by a collineation of Π if n 6= 4...

Let G0, . . . ,Gk be finite abelian groups, and let G0 ∗ · · · ∗ Gk be the join of the 0-dimensional complexes Gi . We give a characterization of the integral k-coboundaries of subcomplexes of G0 ∗ · · · ∗Gk in terms of the Fourier transform on the group G0 × · · · × Gk . This provides a short proof of an extension of a recent result of Musiker and Reiner on a topological interpretation of the ...

The Goto-Kakizaki (GK) rat, which has been developed by repeated inbreeding of glucose-intolerant Wistar rats, is the most widely studied rat model for Type 2 diabetes (T2D). However, the detailed genetic background of T2D phenotype in GK rats is still largely unknown. We report a survey of T2D susceptible variations based on high-quality whole genome sequencing of GK and Wistar rats, which hav...

A major open problem in communication complexity is whether or not quantum protocols can be exponentially more efficient than classical ones for computing a total Boolean function in the twoparty interactive model. The answer appears to be “No”. In 2002, Razborov proved this conjecture for so far the most general class of functions F (x, y) = fn(x1 · y1, x2 · y2, ..., xn · yn), where fn is a sy...

Glucokinase plays a key role in the regulation of glucose utilization in liver and its expression is strongly enhanced by insulin and modulated by venous pO(2). In primary rat hepatocytes, pO(2) modulated insulin-dependent glucokinase (GK) gene expression was abolished by wortmannin an inhibitor of phosphatidylinositol 3-kinase (PI3K). Transfection of vectors encoding the p110 catalytic subunit...

Abstract By modifying constructions of Bĕıdar and Small we prove that for countably generated prime F -algebras of finite GK dimension there exists an affinization having finite GK dimension. Using this result we show: for any field there exists a prime affine algebra of GK dimension two that is neither primitive nor PI; for any countable field F there exists a prime affine F -algebra of GK dim...

Let Mn be a linear hyperplane arrangement in IR. We define finite posets Gk(M) and Vk(M) of oriented matroids associated with this, which approximate the Grassmannian Gk(IR) and the Stiefel manifold Vk(IR), respectively. The basic conjectures are that the “OM-Grassmannian” Gk(M) has the homotopy type of Gk(IR), and that the “OM-Stiefel bundle” ∆π : ∆Vk(M) −→ ∆Gk(M) is a surjective map. These co...

Let P and P ′ be (2k + 1)-dimensional Pappian projective spaces. Let also f : P → P∗ and f ′ : P ′ → P ′∗ be null systems. Denote by Gk(f) and Gk(f ′) the sets of all invariant k-dimensional subspaces of f and f ′, respectively. In the paper we show that if k ≥ 2 then any mapping of Gk(f) to Gk(f ′) sending base subsets to base subsets is induced by a strong embedding of P to P ′. MSC 2000: 51M...