Objective To describe a case of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy refractory to immunotherapy without evidence malignancy or coexisting autoimmunity. Background Autoimmune GFAP is an disease the central nervous system associated with presence GFAP-IgG in CSF. Patients may present acute subacute onset headache, encephalopathy, seizures, abnormal vision, weakness nu...

The present study examined whether nestin+ neural-like stem cells detected in the scar tissue of rats 1 week after myocardial infarction (MI) were derived from bone marrow and/or were resident cells of the normal myocardium. Irradiated male Wistar rats transplanted with beta-actin promoter-driven, green fluorescent protein (GFP)-labeled, unfractionated bone marrow cells were subjected to corona...

Cervical glial polyps or gliosis of uterine cervix are rare. These are rare polypoidal mesenchymal tumours and usually manifest with vaginal bleeding, post-coital bleeding or cervical discharge. Microscopically these polyps show heterotopic glial tissue with varying degree of gliosis. Immunoperoxidase staining with Glial fibrillary acidic protein (GFAP) confirms the glial nature of the polyp. C...

Abstract The current study deals with the effect of N-Diethylnitrosamine (DEN) induced traumatic brain injury on male albino rats, as well outcome results treatment paclitaxel nanoparticles for a period 8 weeks two-week intervals is concern present study. Mean body weight, was considered main parameters whereas detailed immunohistochemical rat sections performed. Astrocytic biomarkers diagnosis...

we report two cases of de novo gemistocytic glioblastomas. in case one, a 35 year male presented with features of raised intracranial pressure and rapid neurological deterioration. in case 2; a 73 year old male presented with rapid neurological deterioration and focal neurological deficits. in both cases imaging findings were suggestive of high grade malignancy involving the brain. this was con...

The lateral geniculate nucleus, which lies between the retina and the striate cortex in the visual pathway of mammals, is often made up of several distinctive cell layers, or laminae. We have used immunohistochemical methods to localize two glial cell intermediate filament proteins, glial fibrillary acidic protein and vimentin, and have found that layering of glial cells is evident before neuro...

doi : 10.5214/ans.0972.7531.190412 Mouse eye-sections showing GFAP expression in a stroke-induced retinal ischemia model. Immunoflourescent staining of mouse eye-sections for glial fibrillary acidic protein (GFAP) expression after 60 minutes of middle cerebral artery occlusion (MCAo) and 23 hours of reperfusion. (A) DAPI stained section (B) Section showing increased GFAP expression(Images taken...

Cdk5 exists in brain extracts in multiple forms, one of which is a macromolecular protein complex comprising Cdk5, neuron-specific Cdk5 activator p35nck5a and other protein components (Lee, K.-Y., Rosales, J. L., Tang, D., and Wang, J.H. (1996) J. Biol. Chem. 271, 1538-1543). The yeast two-hybrid system was employed to identify p35nck5a-interacting proteins from a human brain cDNA library. One ...

The localization of vimentin (VIM) and glial fibrillary acidic protein (GFAP) was studied immunohistochemically in adult rat optic nerve. Consecutive Epon semithin tissue sections were immunostained respectively for VIM or GFAP. With this method, both antigens were detected in consecutive sections of the same cell. According to our results, most astrocytes in the adult rat optic nerve showed co...