Diminished responsiveness to hypoglycemia contributes to defective counterregulation in diabetes. Pancreatic and/or circulating somatostatin are elevated in diabetes, which may inhibit counterregulatory hormone release during hypoglycemia. Thus, a selective somatostatin receptor type 2 antagonist (SSTR2a) should improve hormone counterregulation to hypoglycemia. Nondiabetic (N) and streptozotoc...

Superparamagnetic iron oxide nanoparticles have been coated with a low affinity CXCR4 receptor antagonist to give high multivalent binding construct.

introduction: we previously shown that microinjection of glutamate into the hdb of rat elicited cardiovascular depressive responses. microinjection of ap5 (an nmda receptor antagonist, 2.5 mm, 50 nl) and cnqx (an ampa receptor antagonist, 1 mm, 50 nl) caused no significant changes in the blood pressure and heart rate. microinjection of bicuculline (bmi: a gabaa receptor antagonist, 1 mm, 50 nl)...

Polyclonal antibodies were prepared against synthetic peptides corresponding to four different extramembrane segments of the rat glucagon receptor. The antibodies bound specifically to native glucagon receptor as judged by immunofluorescence microscopy of cultured cells expressing a synthetic gene for the receptor. Antibodies to peptides designated PR-15 and DK-12 were directed against amino ac...

Cellular responses to adenosine depend on the distribution of the two adenosine receptor subclasses. In primary cultures of rat hepatocytes, adenosine receptors were coupled to adenylate cyclase via A1 and A2 receptors which inhibit and stimulate cyclic AMP production respectively. R-(-)-N6-(2-phenylisopropyl)-adenosine (R-PIA), the adenosine A1 receptor-selective agonist, inhibited glucagon-st...

A 9-year-old boy affected by colchicine-resistant idiopathic pericarditis was successfully treated with an IL-1 receptor antagonist (anakinra).

KEY POINTS Arginine vasopressin (AVP) stimulates the release of enteroendocrine L-cell derived hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in vitro from mouse and human colons. This is mediated by the AVP receptor 1B, which is highly enriched in colonic L-cells and linked to the elevation of L-cell calcium and cAMP concentrations. By means of Ussing chambers, we show that AVP ...

Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...

Introduction: We previously shown that microinjection of glutamate into the hDB of rat elicited cardiovascular depressive responses. Microinjection of AP5 (an NMDA receptor antagonist, 2.5 mM, 50 nl) and CNQX (an AMPA receptor antagonist, 1 mM, 50 nl) caused no significant changes in the blood pressure and heart rate. Microinjection of bicuculline (BMI: a GABAA receptor antagonist, 1 mM, 50...