Medicinal plants and their derivations are used as safe agents for the treatment of parasitic diseases. This preliminary study investigates antileishmanial activities Peganum harmala essential oil (PHEO), Achillea millefolium oils (AMEO) combinations against Leishmania infantum promastigotes. A standard strain L. promastigote was cultured in a 96-well Novy-MacNeal-Nicolle media culture glucanti...

BACKGROUND This study was conducted to explain the trend of Cutaneous Leishmaniasis (CL) in Kermanshah Province, western Iran from 1991-2012. METHODS In this analytical-descriptive study, all of the patients suspected to CL in Kermanshah Province were studied. Smears were prepared from most of them, stained with Giemsa, and examined microscopically for Leishman bodies. A few of the patients w...

objective: leishmaniasis is one of the six most common parasitic infections in tropical regions. there are different therapeutic modalities. however therapeutic resistance is developed and resulted in numerous problems. so evaluation of other therapeutic modalities is performed extensively. we compared the therapeutic response of cutaneous leishmaniasis with glucantime and garlic extract and it...

Background & Aims: Leishmaniasis exists in more than half of Iran provinces and more than 20,000 cases are reported annually. In the recent years, several therapeutic approaches such as topical and physical treatments have been investigated. In the present study, the efficacy of co-administration of topical Niosomal Dapsone gel and Glucantime intralesional injection has been evaluated. Method: ...

INTRODUCTION Visceral leishmaniasis is a public health problem, with lethality reaching 10%. The recommended drug treatment is methylglucamine antimoniate. This study aimed to evaluate drug use for cases of visceral leishmaniasis treated at the Infectology Clinic of the Campo Grande University Hospital Center, State of Mato Grosso do Sul. METHODS To collect data, we examined the medical recor...

LTB 131, a 12 year old boy, came to the clinic with a typical leishmania ulcer on his right leg (20mm in diameter with a raised rolled edge) present for 6 months. Neither giemsa stained smears nor hamster inoculation showed evidence of parasites. Histology was compatible with the clinical diagnosis. The leishmanin test (using a 30ju,g dose of protein) was negative in 1980,1981, twice in 1983 (a...

An in vitro investigation was carried out to assess how the lipopeptide biosurfactant (LPB) produced by Acinetobacter junii B6 affects Leishmania tropica infection and associated cytokine gene expression macrophages infected with L. tropica. Glucantime® (meglumine antimoniate, MA) LPB were investigated for their leishmanicidal effect, alone combination (LPB + MA), using a colorimetric test macr...