نتایج جستجو برای: glucantime resistant
تعداد نتایج: 192640 فیلتر نتایج به سال:
Background and Aim: Leishmaniasis is a parasitic disease transmitted by sand-flies. Seventeen out of the 30 Iranian provinces are contaminated. Although many therapeutic modalities have been suggested, no definite treatment for this widespread infection is available. Many drugs currently used for cutaneous leishmaniasis have their side effects and create complications-drug resistance, etc. This...
ABSTRACT Background and objectives: Leishmania major is a flagellated parasitic protozoan that causes cutaneous leishmaniasis. Pentavalent antimony compounds are considered the first-line drugs in the treatment of cutaneous leishmaniasis. However, the use of these drugs is associated with numerous limitations and side effects. Theref...
Objective(s): Because leishmaniasis is related to the impaired functioning of T-cells, the use of an immunomodulator can increase the efficacy of antileishmanial therapy in visceral leishmaniasis. In this study, we used shark cartilage extract with artemisinin and glucantime against visceral leishmaniasis in BALB/c mice, and evaluated the synergistic therapeutic effect. Materials and Methods: Th...
objective(s):cutaneous leishmaniasis is a common and endemic disease in khorasan province in north-east of iran. the pentavalant antimony (sb v) is the mainstay of treatment that has many side effects and resistance to the drug has been reported. the microbicidal effect of ozone was proven in different microorganisms. since there is no study in this respect and to achieve a low cost and effecti...
background: recent circumstantial evidences are suggesting that an increasing number of iranian patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate (glucantime®). pistacia atlantica is native plant in iran (central, western, and eastern regions). gum obtained pistacia atlantica has been reported to possess considerable in vitro antimicrobial activity. in this study...
BACKGROUND Visceral leishmaniasis (VL) is a neglected parasitic disease that is fatal if left untreated. VL is endemic in Morocco and other countries in North Africa were it mainly affects children from rural areas. In Morocco, the direct observation of Leishmania parasites in bone marrow aspirates and serological tests are used to diagnose VL. Glucantime is the first line of treatment. The obj...
In many tropical areas, infections by Leishmania species are endemic and include visceral leishmaniasis (VL), which is often fatal if untreated. Outside India, VL treatment and control are based on long-term administration of highly toxic pentavalent antimonials. Previously, we described the synthesis and in vitro leishmanicidal activity of a series of nine benzophenone derivatives with low tox...
Popular perceptions and knowledge about cutaneous leishmaniasis and its treatment were studied in an endemic area of subtropical Northwest Ecuador. Although most of the adults surveyed were familiar with the disease, the vector, and traditional treatments, many showed a lack of knowledge about transmission of the disease, ulcer healing, and conventional treatment. Gender was found to have a sig...
background: successful therapy of leishmaniasis depends on effective cellular immune response. we evaluated the effectiveness of sodium selenite and zinc sulphate as known immunomodulator materials, in combination with glucantime® in treatment of cutaneous leishmaniasis lesions resulting from leishmania major in susceptible animal model. methods: thirty three female mice weighing 18-20 g at th...
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