diabetes type 2 is a world wide spread disease with a multifactorial pathogenetic evolution. various factors like obesity, physical inactivity and poor lifestyle habits contribute to its development. the aim of this study was to verify if in young healthy sedentary male and female there is positive correlation between family history to type 2 diabetes and an increase in body weight and fat mass...

Activation of AMP-activated protein kinase (AMPK) in cardiomyocytes induces translocation of glucose transporter GLUT4 and long-chain fatty acid (LCFA) transporter CD36 from endosomal stores to the sarcolemma to enhance glucose and LCFA uptake, respectively. Ca(2+)/calmodulin-activated kinase kinase-β (CaMKKβ) has been positioned directly upstream of AMPK. However, it is unknown whether acute i...

Gastric cancer (GC) is one of the common reasons of cancer-related death with few biomarkers for diagnosis and prognosis. Solute carrier family 2 (facilitated glucose transporter) member 1 protein SLC2A1, also known as glucose transporter type 1 (GLUT1), has been associated with tumor progression, metastasis, and poor prognosis in many human solid tumors. However, little is reported about its c...

Obesity is classified as a low-grade chronic inflammatory disease. Obesity-induced inflammation associated with the development of insulin resistance (IR). In this study, we investigated effects Mesembryanthemum crystallinum extract (MCE) on tumor necrosis factor-alpha (TNF-α)-induced and IR in 3T3-L1 adipocytes, well underlying mechanisms. Lipolysis was monitored by oil red O staining. Glucose...

Background: Sodium-Glucose Co-Transporter-2 Inhibitors (SGLT2-IS) have been shown to increase hemoglobin (Hb) levels, hematocrit, and erythrocyte count. It has also found that these agents can potentially reduce the risk of anemia minimize need for erythropoiesis stimulating (ESA) other treatments in patients with type 2 diabetes (T2D) chronic kidney disease (CKD). However precise mechanism suc...

One of the leading causes diabetes-related deaths is myocardial damage, which may be cause heart failure in people with type 2 diabetes mellitus. The objective research was to look at impact coronary kind a pair This project aimed explore protective oleanolic acid on damage mellitus and investigate connected mechanism. Specific pathogen free grade db/db male mice were elected as model, while Db...

Glucose sensing in the brain has been proposed to be involved in regulating food intake, but the mechanism is not known. Glucose transporter type 2 (GLUT2)-null mice fail to control their food intake in response to glucose, suggesting a potential role for this transporter as a glucose sensor in the brain. Here we show that individuals with a genetic variation in GLUT2 (Thr110Ile) have a higher ...