Abscisic acid production by Cercospora rosicola Passerini in liquid shake culture was measured with different amino acids in combination and singly as nitrogen sources and with different amounts of thiamine in the media. Production of abscisic acid was highest with aspartic acid-glutamic acid and aspartic acid-glutamic acid-serine mixtures as nitrogen sources. Single amino acids that supported ...

Previous studies of the S1 subunit of pertussis toxin, an NAD(+)-dependent ADP-ribosyltransferase, suggested that a small amino-terminal region of amino acid sequence similarity to the active fragments of both cholera toxin and Escherichia coli heat-labile enterotoxin represents a region containing critical active-site residues that might be involved in the binding of the substrate NAD+. Other ...

Deoxynivalenol (DON) has various toxicological effects in humans and pigs that result from the ingestion of contaminated cereal products. This study was conducted to investigate the protective effects of dietary supplementation with glutamic acid on piglets challenged with DON. A total of 20 piglets weaned at 28 d of age were randomly assigned to receive 1 of 4 treatments (5 piglets/treatment):...

The effect of glutamic acid and glutamine on glycolysis is one of the few examples of a direct and apparently specific action of amino acids on a particular phase of carbohydrate metabolism. Glutamine has been shown to stimulate glycolysis in Streptococcus hemolyticus (1) and in iron-deficient cells of Clostridium tetuni (2). Glutamine, glutamic acid, and related compounds have also been report...

Using cortical neuronal cultures and glutamic acid excitotoxicity and oxygen-glucose deprivation (OGD) stroke models, we demonstrated that poly-arginine and arginine-rich cell-penetrating peptides (CPPs), are highly neuroprotective, with efficacy increasing with increasing arginine content, have the capacity to reduce glutamic acid-induced neuronal calcium influx and require heparan sulfate pre...

The occurrence of free glutamine in plant tissue extracts has been recognized for a considerable time, but its presence in the protein-free filtrates of mammalian tissues was established only recently (1). The functional significance of the free amide in tissues cannot be appreciated without a knowledge of its quantitative relationship to glutamic acid and of the biological mechanisms regulatin...

The synthesis of citrulline from ornithine and arginine from citrulline has heretofore been associated only with intact liver cells. In the course of studies on the mechanism of the conversion of citrulline to a&nine, a highly active system was found in liver homogenate capable of forming urea in the presence of glutamic acid, adenosine triphosphate (ATP), cytochrome c, an oxygen atmosphere, an...

In urea synthesis, according to the Krebs-Henseleit ornithine cycle (l), the transfer of nitrogen to citrulline to form arginine (Step II) was thought to occur from NH$. It was not until Cohen and Hayano (2) succeeded in demonstrating rapid arginine synthesis in liver homogenates from glutamic acid and citrulline that the transfer from an amino acid rather than from NH, was recognized as a main...

L-Glutamic, L-aspartic acids and a number of their structural analogs, including quisqualic, kainic, ibotenic, quinolinic, and N-methyl-D-aspartic (NMDA) acids, increase inositol phospholipid hydrolysis when added to primary cultures of cerebellar granule cells, as is reflected by an enhanced formation of 3H-inositolmonophosphate (3H-IP1) in the presence of Li+. L-Glutamic acid also enhances th...