Colorimetric recognition and sensing of sulfide with high selectivity by virtue of glutathione-modified gold nanoparticle (GSH-AuNP) is presented. The assay is developed based on a specific anion-for-molecule ligand exchange reaction, through which sulfide replaces glutathione self-assembled on the AuNP. The unique feature of the GSH-AuNP probe makes it a novel colorimetric sensor for sulfide.

A comparison of the erythrocyte (RBC) antioxidant metabolites and enzymes in nine marsupial and two monotreme species was carried out. Reduced glutathione (GSH) concentrations were comparable with those reported for other marsupial and eutherian species. An important finding was that the erythrocytes of the southern hairy nosed wombat regenerated GSH faster than the erythrocytes from its close ...

2,2'-Dihydroxychalcone (2,2'DHC) is a potent inhibitor of glutathione S-transferases (GSTs). Pre-treatment of human colon cancer cells by a non-toxic concentration of this GST inhibitor significantly sensitised cancer cells to chlorambucil and melphalan, which are substrates of glutathione (GSH) conjugation. However, sensitisation to actinomycin D, which has not been shown to be detoxified by G...

Glutathione (GSH) plays important roles in antioxidant defense, nutrient metabolism, and regulation of cellular processes, including cell differentiation, proliferation and apoptosis. Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and pathogenesis of many diseases, one of which is cancer. The GSH content of cancer cells is associated with multidrug and r...

The paper reviews a recent research on the role of glutathione (GSH) in the male and female germ cells as well as during the early stages of embryo development in mammals. In both the male and female gametes, GSH is involved in the protection of these cells against oxidative damage. Glutathione has been implicated in maintaining the meiotic spindle morphology of the oocyte. After fertilization,...

PURPOSE Bisretinoids such as A2E that accumulate as components of the lipofuscin of retinal pigment epithelial cells are implicated in some retinal disease processes. These compounds undergo light-induced oxidation and cleavage with the latter releasing of a mixture of aldehyde-bearing fragments, including dicarbonyl methylglyoxal. We tested for the reactivity of photooxidation and photodegrada...

Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione levels. Using a glutaredoxin sensor (sCGrx1pER), which rapidly and specifically equilibrates with the reduced glutathione (GSH)-glutathione disul...

A straightforward method for the rapid detection of the presence of glutathione S-transferase (GST)-tagged proteins from sample solutions using glutathione (GSH)-bound gold nanoclusters (Au@GSH NCs) with luminescence properties as the detection probes by simple observation with the naked eye was proposed in this study.

The aim of this study was to evaluate the antioxidant activity exopolysaccharides (EPS) from Lactobacillus kimchi SR8. EPS exhibited strong scavenging activities for 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals. Two fractions (EPS-1 EPS-3) higher than EPS-2. Low-dose CEPS could significantly increase catalase (CAT) glutathione peroxidase (GSH-Px) in serum CAT, GSH-Px superoxide dismutase...