نتایج جستجو برای: glycosyltransferases
تعداد نتایج: 1482 فیلتر نتایج به سال:
Cell-free preparations of the bacterium Acetobacter xylinum were first reported to synthesize cellulose from UDP-Glc over 40 years ago (Glaser, 1958). Despite the elucidation of the primary sequence of the cellulose synthase from this organism in 1990 (Wong et al., 1990), a consistent mechanism to account for the biosynthesis of this and related polysaccharides has remained elusive. Opposing vi...
O of the great riddles of glycobiology is the function of the glycosphingolipids. Their vital role is clear from the fact that the lack only of subsets of glycosphingolipids results in premature death (1). Hundreds of glycosphingolipids populate the surface of mammalian cells. These may serve a general function in membrane structure as their physical properties are different from those of the b...
Bacterial glycosyltransferases (GT) often synthesize the same glycan linkages as mammalian GT; yet, they usually have very little sequence identity. Nevertheless, enzymatic properties, folding, substrate specificities, and catalytic mechanisms of these enzyme proteins may have significant similarity. Thus, bacterial GT can be utilized for the enzymatic synthesis of both bacterial and mammalian ...
Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.
Cell-free preparations of the bacterium Acetobacter xylinum were first reported to synthesize cellulose from UDP-Glc over 40 years ago (Glaser, 1958). Despite the elucidation of the primary sequence of the cellulose synthase from this organism in 1990 (Wong et al., 1990), a consistent mechanism to account for the biosynthesis of this and related polysaccharides has remained elusive. Opposing vi...
Recent research, mostly in Arabidopsis thaliana, has led to the identification and characterization of the glycosyltransferases responsible for the biosynthesis of two of the most functionally important and abundant families of plant cell wall proteins, extensins, and arabinogalactan-proteins. Extensin glycosylation involves monogalactosylation of serine residues by O-α-serine galactosyltransfe...
Aberrant expression of immature truncated O-glycans is a characteristic feature observed on virtually all epithelial cancer cells, and a very high frequency is observed in early epithelial premalignant lesions that precede the development of adenocarcinomas. Expression of the truncated O-glycan structures Tn and sialyl-Tn is strongly associated with poor prognosis and overall low survival. The ...
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