LESSONS LEARNED Percutaneous thermal ablation combined with in situ granulocyte-macrophage colony-stimulating factor cytokine therapy was technically feasible and well tolerated.No significant clinical or immunologic responses were seen. BACKGROUND Melanoma tumor-derived heat-shock proteins (HSPs) and HSP-peptide complexes can elicit protective antitumor responses. The granulocyte-macrophage ...

| A procedure for estimating the joint probability density function (pdf) of T 1 , T 2 , and proton spin density (P D) for gray matter (GM), white matter (WM), and cerebrospinal uid (CSF) in the brain is presented. The pdf's have numerous applications, including the study of tissue parameter variability in pathology and across populations. The procedure requires a multispectral, spin echo magne...

background: &beta-thalassemia; is the most common monogenic disorder in human. the (ct) polymorphism at -158 upstream region of the &gammag-globin; gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin; gene expression and the severity of clinical symptoms of &beta-thalassemia.; methods: in the present study, 51 &beta-thalassemia; intermediate patie...

Reversal of eosinophilic inflammation has been an elusive therapeutic goal in the management of asthma pathogenesis. In this regard, GM-CSF is a primary candidate cytokine regulating eosinophil activation and survival in the lung; however, its molecular mechanism of propagation and maintenance of stimulated eosinophil activation is not well understood. In this study, we elucidate those late int...

The role of the Nuclear Factor κB (NF-κB) transcription factor family in T cell function has been well described. The c-Rel family member is of particular importance in initiating T cell responses to antigen and regulating activation of inflammatory cytokine genes, including the Interleukin-2 (IL-2) and Granulocyte macrophage colony stimulating factor (GM-CSF) genes. c-Rel is required for chrom...

This paper presents a fully differential dualended ultralow-voltage (ULV) FGUVMOS operational transconductance amplifier (FGUVMOS-OTA), and a Gm-C filter where the FGUVMOS-OTA is used. The OTA has no internal nodes, rail-to-rail operation and dynamic load. The cut-off frequency of the Gm-C filter is tunable over more than 5 decades. The circuits may be operated with supply voltages down to 200mV.

As new biotechnologies are developed, the parallels with GM crops are often drawn. In this paper, I consider GM animals and contrast them with GM crops. I use a systems of innovation perspective to consider innovation, product markets and regulatory systems and suggest that whilst there are some parallels between GM crops and animals there are also clear differences. There are differences in th...

Mimicry of peripheral nerve gangliosides by Campylobacter jejuni lipopolysaccharides (LPSs) has been proposed to induce cross-reacting antiganglioside antibodies in Guillain-Barré syndrome (GBS). Because current methods for LPS characterization are labor-intensive and inhibit the screening of large numbers of strains, a rapid GM(1) epitope screening assay was developed. Biomass from two agar pl...

This paper presents a 6 transistor fully differential dualended low-voltage (ULV) FGUVMOS operational transconductance amplifier (FGUVMOS-OTA), and a Gm-C filter where the FGUVMOS-OTA is used. The OTA has rail-torail operation. A basic Gm-C filter implemented with the OTA is presented. The cut-off frequency of the filter is tunable over almost 6 decades with a supply voltage below 1V.

A nucleus, originally at rest, decays radioactively by emitting an electron of momentum 1.73 MeV/c, and at right angles to the direction of the electron a neutrino with momentum 1.00 MeV/c. ( The MeV (million electron volt) is a unit of energy, used in modern physics, equal to 1.60 x 10 erg. Correspondingly, MeV/c is a unit of linear momentum equal to 5.34 x 10 gm-cm/sec.) In what direction doe...