PURPOSE According to current recommendations for adjuvant treatment, patients with colon cancer stage II are not routinely offered chemotherapy, unless considered to have a high risk of relapse based on specific clinicopathological parameters. Following these criteria, it is challenging to identify the subgroup of patients that will benefit the most from adjuvant treatment. Contrarily, patients...

To wait is to live. Every aspect of our existence requires, demands and includes waiting. We wait for our research grants to be funded, our manuscripts to be accepted. For those of us who are on the way up, we wait to be promoted based on our scholarly involvement. Some of us, in fact, most of us are professors of various ranks and disciplines in universities throughout the world. Regardless of...

IN THE PLAY, Waiting for Godot, Godot never arrives. In the context of the “reductionist” (cellular and molecular) wave that has swept over biomedical research during the last 20–30 years, the continuing puzzle of exercise hyperemia is one issue where we may be waiting for the reductionists to address a question that is fundamentally beyond their reach. Part of this is an intellectually combati...

The technology to connect 'things' to the Internet has existed for more than 20 years, so if we take a look back at recent history we might well be tempted to ask the question why will IoT ‘happen’ this time around. In this paper we examine the origins of the Internet of Things, answer the question "Why Now?", and look forward to the next wave of disruptive technologies that will be coming to a...

In this issue’s Editors choice, Aoife Moran, Anne Scott and Philip Darbyshire (see page 70) argue that the process of living on haemodialysis, while waiting for a kidney transplant, is one in which time is both killed and wasted. Rather like the lives of the protagonists in Beckett’s Waiting for Godot, the lives of people on dialysis are ones characterised by existential boredom. Moreover, thei...

While film has long utilised computers to create otherwise impossible characters, similar use within live stage performances is relatively uncommon. Even within film, these characters have, until recently, been mere puppets controlled by some form of puppeteer. This paper outlines research carried out at Massey University into autonomous synthetic (computer) actors that are capable of learning ...