Biosynthesis of gold nanoparticles has emerged as an important area in nanotechnology and biotechnology due to growing need to develop environmentally benign technologies. Generally, nanoparticles are prepared by a variety of chemical methods which are not environmentally friendly. In the present study, we report a rapid and convenient method to reductively prepare gold nanoparticles from auric...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...

background: hadron therapy for malignant tumor is becoming increasingly popular. there are many factors which effect on implementation of a proper treatment planning. the purpose of this work is to investigate the inhomogeneity effects as affecting factor on proton range, full width at half maximum (fwhm) and 20% position of penumbra (p20) by mcnpx code. materials and methods: an inhomogeneous ...

The development of reliable processes for the synthesis of gold nanoparticles is an important aspect of current nanotechnology research. Recently, reports are published on the extracellular as well as intracellular biosynthesis of gold nanoparticles using microorganisms. However, these methods of synthesis are rather slow. In present study, rapid and extracellular synthesis of gold nanoparticle...

Marine actinobacteria-produced fucoidanases have received considerable attention as one of the major research topics in recent years, particularly for the medical exploitation of fucoidans and their degradation products. The present study describes the optimization and production of a novel fucoidanase for the green synthesis of gold nanoparticles and its biological applications. The production...

Mesenchymal stem cells are widely used in many pre-clinical and clinical settings. Despite advances in molecular technology; the migration and homing activities of these cells in in vivo systems are not well understood. Labelling mesenchymal stem cells with gold nanoparticles has no cytotoxic effect and may offer suitable indications for stem cell tracking. Here, we report a simple protocol to ...

The effect of gold nanoparticles on lung cancer cells is not yet clear. In this study, we investigated the cytotoxicity and cell invasion activity of lung cancer cells after treatment with gold nanoparticles and showed that small gold nanoparticles can be endocytosed by lung cancer cells and that they facilitate cell invasion. The growth of A549 cells was inhibited after treatment with 5-nm gol...

In this study, a novel technique for biosynthesizing of gold nanoparticles (GNPs) using Withania somnifera as reductants and stabilizers is reported. Biosynthesis of anisotropic gold nanoparticles using ethanolic extract of Withania somnifera leaf and their potential as IR blockers has been demonstrated. The phenolic groups (–OH) residue was identified as the active functional group for gold io...

Preparation of gold nanoparticles with a narrow size distribution has enormous importance in nanotechnology. Methanobactin (Mb) is a copper-binding small peptide that appears to function as an agent for copper sequestration and uptake in methanotrophs. Mb can also bind and catalytically reduce Au (III) to Au (0). In this study, we demonstrate a facile Mb-mediated one-step synthetic route to pre...

Gold nanoparticles have diverse applications and are being used in food and cosmetic industry, for drug delivery and in the diagnosis and treatment of cancer. However there is a need to study their biochemical mode of action. In this study, in vivo effect of gold nanoparticles on the activities of the two antioxidant enzymes -superoxide dismutase (SOD) and indoleamine 2,3-dioxygenase (IDO) was ...