The paper titled “The Effects of Fetal Gender on Serum Human Chorionic Gonadotropin and Testosterone in Normotensive and Preeclamptic Pregnancies” [1], published in Journal of Pregnancy, has been retracted as it is found to contain a substantial amount of material from the paper “Human chorionic gonadotropin and testosterone in normal and preeclamptic pregnancies in relation to fetal sex,” auth...

Clinical findings and endocrine studies are reported concerning six subjects (from two pedigrees) suffering from isolated hypogonadotropic hypogonadism. Their complete lack of any gonadotropin response to clomiphene stimulation, together with positive responses of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to LH-releasing-hormone stimulation (LH-RH) provide evidence for a h...

The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the ...

A study was carried out to observe the influence of enucleation on the excretion of a gonadotropin-inhibiting substance in male rats. No significant difference in the inhibitory effect on the ovulation induced with PMS and HCG was observed between the urinary extracts of the intact and blinded rats. The observations suggest that effect of blindness on the secretion of a gonadotropin-inhibitor w...

Since a gonadotropin-inhibiting substance in human urine is precipitated by acidification of urine, comparisons of the gonadotropic activities and the inhibitory effects in urine after acidification and removal of precipitate and in untreated urine were carried out in bioassays. Gonadotropic activity in the supernatant of acidified urine, in which a gonadotropin-inhibitor was removed through pr...

(Abstracted from J Natl Cancer Inst 2021;113:699–709) Despite inconclusive evidence, concerns that assisted reproductive technology may be associated with increased risk of ovarian cancer remain. Significant increases in gonadotropin levels and disruption epithelium have been proposed as mechanisms to explain this potential association.

The study of gene expression in gonadotropes has largely focused on the variety of mechanisms regulating transcription of the gonadotropin genes and ancillary factors that contribute to the overall phenotype and function of these cells in reproduction. However, there are aspects of the response to GNRH signaling that are not readily explained by changes at the level of transcription. As our und...

Traditionally, ovulation induction (OI) with intrauterine insemination (IUI) has been a strategy used to maximize pregnancy outcomes in patients attempting pregnancy. A common pattern of performing OI/IUI historically has been to begin OI using oral medications, such as Clomiphene Citrate or Letrozole, and then escalating medical management to include injectable Gonadotropins such as follicle s...

BACKGROUND To measure low neonatal gonadotropin levels, a sensitive non-invasive method is optimal. The aim of the current study was to validate the Architect i2000SR, an automated immunoassay analyser for the measurement of gonadotropins in unextracted neonatal urine samples against serum gonadotropin levels as a gold standard. METHODS Blood and urine were sampled from 30 approximately six-w...