Digital zero-sum games are a challenging domain for artificial intelligence techniques. In such games, human players often resort to strategies, i.e., memorized sequences of lowlevel actions that guide their behavior. In this research we model this way of playing by introducing the algorithm selection metagame, in which agents select algorithms to perform low-level game actions on their behalf....

Studies indicate that information systems and computer science programs should place more emphasis on software design topics. Because little significant software in a commercial environment is developed using only programming skills, students without exposure to design patterns and frameworks will be ill-prepared for the workforce. This paper investigates whether PHP-based web development cours...

The care for patients with acute ischemic stroke has been revolutionized by the clinical application of fibrinolysis. Intravenous recombinant tissue plasminogen activator (rt-PA) has been proven to improve functional outcomes following acute ischemic stroke and can be administered to a select group of patients up to 4.5 h after symptom onset. Time from symptom onset to thrombolysis is the most ...

Partial Least Squares (PLS) based Structural Equation Modeling (SEM) has become increasingly popular in Management Information Systems (MIS) research to model complex relationships and to make valid inferences from the restricted sample to the larger population. Given the larger goal of creating generalizable theories in MIS research, we argue that the lack of model selection criteria in PLS th...

Motor neurons extend axons along specific trajectories, but the molecules that control their pathfinding remain poorly defined. We show that two LIM homeodomain transcription factors, Lim1 and Lmx1b, control the initial trajectory of motor axons in the developing mammalian limb. The expression of Lim1 by a lateral set of lateral motor column (LMC) neurons ensures that their axons select a dorsa...

To generate human antibodies against CXCR4, a seven-transmembrane chemokine receptor and a principal coreceptor for HIV-1, several rounds of Pathfinder and Step-back selection from a large phage display antibody library were performed on Jurkat cells. A mAb against CXCR4 or biotinyated phage antibodies were used as guide molecules. Over 100 pan-Jurkat-cell-positive antibodies were characterized...

The authors present a case of immediate loading of mandibular implants using a 5-step procedure. The first step consists of building a scannographic template, the second step consists of taking a computerized tomographic (CT) scan, and the third step consists of implant planning using SurgiCase software. The final 2 steps consist of implant placement using a drill guide created by stereolithogr...

This paper presents a critical review of the work published at ICSE’2016 on a practical guide of quality indicator selection for assessing multiobjective solution sets in search-based software engineering (SBSE). This review has two goals. First, we aim at explaining why we disagree with the work at ICSE’2016 and why the reasons behind this disagreement are important to the SBSE community. Seco...

Background:  A significant increase in cesarean section in worldwide is known as one of the health system problems. The WHO has estimated that cesarean section in recent years has been 10% in all countries. Despite the increasing popularity of cesarean section, the literature lacks insights about factors affecting the selection of this delivery method. In this vein, this study investigates the ...

Survival in the natural world demands the selection of relevant visual cues to rapidly and reliably guide attention towards prey and predators in cluttered environments. We investigate whether our visual system selects cues that guide search in an optimal manner. We formally obtain the optimal cue selection strategy by maximizing the signal to noise ratio (SNR) between a search target and surro...