BACKGROUND Iodine 125 (125I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on apoptosis, expression of DNA methyltransferases (DNMTs) and cell growth in pancreatic cancers. MATERIALS AND METHOD...

BACKGROUND Radiation induced secondary cancers are a rare but severe late effect after breast conserving therapy. Intraoperative radiotherapy (IORT) is increasingly used during breast conserving surgery. The purpose of this analysis was to estimate secondary cancer risks after IORT compared to other modalities of breast radiotherapy (APBI - accelerated partial breast irradiation, EBRT - externa...

Volumetric-modulated arc therapy (VMAT) plans may require more control points (or segments) than some of fixed-beam IMRT plans that are created with a limited number of segments. Increasing number of control points in a VMAT plan for a given prescription dose could create a large portion of the total number of segments with small number monitor units (MUs) per segment. The purpose of this study...

Background & Aims: Today, different imaging techniques have been studied in the reading of radiationsensitive polymer gels dosage. Due to limitations of imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT), ultrasound techniques are proposed for dose-dependent parameter extraction. In this study, using MAGIC-f (methacrylic and ascorbic acid in gelatin initiat...

Four large randomised controlled trials testing modest hypofractionation for localised prostate cancer have reported efficacy and side effect outcomes within the last year (1-8). The studies were designed using different strategies which need to be considered when interpreting their results. The two largest trials, CHHiP (3,216 patients) (1-3) and PROFIT (1,206 patients) (4), have much in commo...

BACKGROUND Radiotherapy can effectively palliate the symptoms of poor-prognosis patients with non-small-cell lung cancer. However, controversy remains about whether short-course or more protracted radiotherapy schedules provide better value for the money. We conducted a societal cost-utility analysis of a Dutch multicenter randomized trial with 1-year follow-up that compared the efficacy of rad...