The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assaying for such complex phenomena in mammalian models. The zebrafish has emerged as a powerful animal model for chemical screening in many contexts. Several chara...

The rst part of this thesis concerns the formulation of numerical methods that are local in time for the solution of equations with memory. The main idea is that the solution will be updated in the Fourier domain in order to avoid evaluating time convolution integrals that have memory. This work was made possible by the development of a good quadrature[31] of the Fourier integral where a small ...

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Every effort should be made to achieve the best possible results at the time of lip and palate repair. Appropriate and extensive evaluation, short- and long-term planning with optimal timing for each procedure, close cooperation with the members of the craniofacial team, selection of the most appropriate technique(s), careful execution, and close follow-up are prerequisites for success. Additio...

ORE than a year has elapsed since the publication of the long awaited and sorely needed terminology and classification manual, made possible through the joint sponsorship of the United States Department of Health, Education and Welfare and the American Association on Mental Deficiency (Heber, 1959). Despite the considerable significance this manual will have in aiding the establishment of a com...

This Habilitation thesis outlines my research activities carried out as an Associate Professor at Université ParisSud and Inria Saclay Île-de-France. During this period, from 2003 to early 2012, my work was – and still is – at the interface between Knowledge Representation and Databases. I have mainly focused on ontology-based data management using the Semantic Web data models promoted by W3C: ...

Inspired by the coordinated beating of the flagellar pair of the green algae Chlamydomonas, we study theoretically a simple, mirror-symmetric swimmer, which propels itself at low Reynoldsnumber by a revolving motion of a pair of spheres. We show that perfect synchronization between thesetwo driven spheres can occur due to the motion of the swimmer and local hydrodynamic friction forces....

This paper presents a formal behavioural specification framework for specifying and verifying the correct behaviour of distributed Fractal components. The first contribution is a parameterised and hierarchical behavioural model called pNets that serves as a lowlevel semantic framework for expressing the behaviour of various classes of distributed languages and as a common internal format for ou...