Obstructive sleep apnea is characterized by upper airway collapse, leading to intermittent hypoxia (IH). It has been postulated that IH-induced oxidative stress may contribute to several chronic diseases associated with obstructive sleep apnea. We hypothesize that IH induces systemic oxidative stress by upregulating NADPH oxidase, a superoxide-generating enzyme. NADPH oxidase is regulated by a ...

Early nutritional deprivation might cause irreversible damage to the brain. Prenatal exposure to undernutrition has been shown to be associated with increased central nervous system anomalies at birth and decreased cognitive function in adulthood. Little is known about the potential effect on the brain in older age. We investigated brain size and structure at age 68 years after prenatal famine ...

The purpose of this paper is to describe a learning model based on Storytelling and its application in the context of legal education helping build challenging training resources that explain, to common citizens with little or no background about legal topics, concepts related to Legal Mediation in general and in specific areas like e-commerce and civil liability. The defined model has been con...

although england and the united states are both common law states and their legal systems follow the same rules, each has disregarded certain rules and changed them to suit specific circumstances. for instance, they have both disregarded the common law rule on the insertion of exemption conditions by carriers. regarding carrier’s liability towards passengers, the united states accepts the highe...

the effect of silence in civil litigation is important in two cases: the silence of litigants (plaintiff and defendant) and silence in evidence of proof of claim. although the general rule is that silence cannot express the will and, therefore, is not entitled to the legal effects and any responsibility, but the silence of plaintiff and defendant has been deemed refusal and it has legal effect....

the system of land registration is protective formalism that is formed based on the theory of “public confidence”. this theory presumes that what reflected by the land registration offices is based on the legal fact. this theory, which provides legal stability and security in transactions, is manifested in three guiding principles including “mirror principle”, “curtain principle” and “insurance...