UNLABELLED The treatment of diabetic retinopathy (DR) is one of the most challenging problems in ophthalmology. The possibility of modulating DR by successful combined kidney and pancreas transplantation thus holds an attractive promise for the ophthalmologist. From June 1983 until April 1997, a total of 86 combined kidney and pancreas transplantation procedures were performed at the Prague-bas...

OBJECTIVE To determine prevalence, genetic and phenotype characteristics of patients with hepatocyte nuclear factor-1α (HNF1A) variants in the Diabetes Patienten Verlaufsdokumenation (DPV) multicentre database and to examine the influence of HNF1A mutation type, or location on clinical phenotypes. PATIENTS AND METHODS Seventy-one DPV patients were labelled as HNF1A-MODY (MODY3). Forty-four pa...

The study aims to investigate the effect of vitamin D (VD) combined with pioglitazone hydrochloride (PIO) on bone mineral density (BMD) and bone metabolism in patients with Type 2 diabetic nephropathy (T2DN). T2DN patients were selected and assigned into mild, moderate, and severe groups. In each group, three therapy regimens (VD, PIO, and VD plus PIO) were administered. X-ray absorptiometry wa...

BACKGROUND/AIM [corrected] During the first 10 years over 50% of diabetes patients develop erectile dysfunction (ED). It is more severe and resistant to therapy than in male patients with normal glucoregulation. The purpose of this pilot study was to estimate the tadalafil (Cialis) efficacy and safety in male patients with diabetes mellitus (DM), together with moderate to severe ED. METHODS T...

BACKGROUND Acute phase mediators promote metabolic changes by modifying circulating hormones. However, there is virtually no data about the link between glucagon and inflammatory parameters in obesity-related chronic low-grade inflammation. STUDY DESIGN We performed both cross-sectional and longitudinal (diet-induced weight loss) studies. METHODS Circulating glucagon concentrations (ELISA),...

The objective of this study was to determine whether the combination therapy of intrapancreatic autologous stem cell infusion (ASC) and hyperbaric oxygen treatment (HBO) before and after ASC can improve islet function and metabolic control in patients with type 2 diabetes mellitus (T2DM). This prospective phase 1 study enrolled 25 patients with T2DM who received a combination therapy of intrapa...

India has the dubious distinction of becoming the diabetic capital of the world within the next few years; with its attendant complications, it is going to burden the resources of the country. The countries with the greatest number of individuals with diabetes in 2013 are China and India. A majority of diabetic patients develop foot ulcers in one point of time or other during the course of thei...

OBJECTIVE Chronic hyperglycemia is known to increase tissue glycation and diabetic complications, but controversy exists regarding the independent role of increased postprandial glucose excursions. To address this question, we have studied the effect of postprandial glycemic excursions (PPGEs) on levels of methylglyoxal (MG) and 3-deoxyglucosone (3-DG), two highly reactive precursors of advance...

OBJECTIVE: The aim of this study was to determine the frequency of skin lesions in type 2 diabetes patients. PATIENTS AND METHODS: A cross-sectional study was conducted at Muhammad Medical College Hospital Mirpukhas, Sindh from July 2008 to December 2009. The sample size comprised of 1270 type 2 diabetes patients. The patients were examined by a physician to determine the presence of diabetes m...

BACKGROUND Endothelial dysfunction is considered as a fundamental and also preventable factor in the progression of vascular complications among type 1 diabetic patient. It occurs before the clinical manifestation of the mentioned complications. The aim of this study was to evaluate the effects of folic acid on endothelial function by measurements of adhesion molecules and von Willebrand factor...