We present a HCN climatology of the years 2002– 2012, derived from FTIR limb emission spectra measured with the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) on the ENVISAT satellite, with the main focus on biomass burning signatures in the upper troposphere and lower stratosphere. HCN is an almost unambiguous tracer of biomass burning with a tropospheric lifetime of 5–6 mon...

By combining molecular biological, electrophysiological, immunological, and computer modeling techniques, we here demonstrate a counterbalancing contribution of TASK channels, underlying hyperpolarizing K+ leak currents, and HCN channels, underlying depolarizing Ih, to the resting membrane potential of thalamocortical relay (TC) neurons. RT-PCR experiments revealed the expression of TASK1, TASK...

Hyperpolarization-activated cyclic nucleotide-gated "HCN" channels, which underlie the hyperpolarization-activated current (Ih), have been proposed to play diverse roles in neurons. The presynaptic HCN channel is thought to both promote and inhibit neurotransmitter release from synapses, depending upon its interactions with other presynaptic ion channels. In larvae of Drosophila melanogaster, i...

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) play a crucial role in the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in brain and heart. HCN channels are principally activated by membrane hyperpolarization and binding of cAMP. Here, we identify tyrosine phosphorylation by Src kinase as another mechanism affecting channel...

Cloud storage system poses new challenges to the community to support efficient concurrent querying tasks for various data-intensive applications, where indexes always hold important positions. A practical method is proposed to construct a two-layer indexing scheme for multi-dimensional data in diverse server-centric cloud storage system. RT-HCN is proposed, which is an indexing scheme integrat...

Observations of molecular clouds, prestellar cores, and protoplanetary disks have established that the HNC/HCN ratio may be a potent diagnostic gas physical conditions. The processes govern relative abundances these molecules nevertheless remain poorly understood. We seek to exploit wide range UV irradiation strengths within 1 pc diameter Helix planetary nebula explore potential role radiation ...

Ion channels play a major role in the regulation of T cell function in health and disease. In a computer-based model, established to simulate T cells’ membrane potential (VM) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. The predicted VM was more hyperpolarized than the measured VM, indicating that a yet unknown, depolarizing ion current might ...

We report deep K-band (18-27GHz) observations with the 100-m Green Bank Telescope of HCN(1 − 0) line emission towards the two submillimeterselected galaxies (SMGs) SMMJ02399−0136 (z = 2.81) and SMMJ16359+6612 (z = 2.52). For both sources we have obtained spectra with channel-to-channel rms noise of σ ≤ 0.5mJy, resulting in velocity-integrated line fluxes better than < ∼ 0.1 Jy km s , although w...

We have imaged the central ∼ 1 kpc of the circumnuclear starburst disk in the galaxy NGC253 in the HCN(1→0), HCO(1→0), and CO(1→0) transitions at 60 pc resolution using the Owens Valley Radio ObservatoryMillimeter-Wavelength Array (OVRO). We have also obtained Atacama Pathfinder Experiment (APEX) observations of the HCN(4→3) and the HCO(4→3) lines of the starburst disk. We find that the emissio...

Plant growth promoting rhizobacteria produce chemical compounds with different benefits for the plant. Among them, HCN is recognized as a biocontrol agent, based on its ascribed toxicity against plant pathogens. Based on several past studies questioning the validity of this hypothesis, we have re-addressed the issue by designing a new set of in vitro experiments, to test if HCN-producing rhizob...