Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described. Therefore, studies for developing more efficient antivirals against HCV are needed. Compounds isolated from animal venoms have shown antiviral activity against some viruses such as Dengue virus, ...

As a relatively simple virus, hepatitis C virus (HCV) depends extensively on its host to infect, replicate and disseminate. HCV has evolved host interactions that result in a restricted tropism, both in terms of cell type and species. Efforts into identifying and validating HCV-host interactions have been hampered by a limited number of infectious virus clones and cell lines that support HCV in...

conclusions this results the same as many similar studies demonstrated that common hcv genotypes in iranian patients were 1a, 3a and 1b, respectively. patients with 1a and 1b genotypes have lower responses to interferon treatment, and it is reasonable to perform early screening to diagnose and determine hcv genotype for effective treatment and diagnose high-risk cases. results in overall, 509 p...

Hepatitis C virus (HCV) is a model for the study of virus-host interaction and host cell responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and this process requires multiple receptors working together. The scavenger receptor class B type I (SR-BI) and claudin-1 (CLDN1), together with human cluster of differentiation (CD) 81 and occludin (OCLN), consti...

Screening blood donations for antibodies against hepatitis C virus (HCV) greatly reduces the risk of transmitting HCV by transfusions. However, despite such screening programs, plasma pools still contain a high percentage of HCV ribonucleic acid as determined by polymerase chain reaction. This result would not be alarming if the procedures for producing blood products included steps to inactiva...

Abstract Hepatitis C virus (HCV) is the serious global public health burden of liver disease. Approximately 170 million people in world are infected with (HCV). In Pakistan, where disease has high occurrence rate. The present study envisages an up-to-date prevalence HCV and genotypic distribution general population Mardan District, Khyber Pakhtunkhwa (KP), Pakistan. blood samples from 6,538 ind...

Hepatitis C virus (HCV) is increasingly common among human immunodeficiency virus (HIV)-infected men who have sex with men. We evaluated the efficacy of HCV core antigen in diagnosing acute HCV in an HIV-infected cohort. Compared with HCV polymerase chain reaction, core antigen proved sensitive (100%) and specific (97.9%). As a quick, simple, and cost-effective test, it has considerable utility...

Background and aim: An epidemiological association of lichen planus (LP) with hepatitis C virus (HCV) infection has been found only in certain parts of the world and in some countries no association has been noted. The present study was done to evaluate the association of LP with HCV in patients admitted to Sina hospital, Hamedan, Iran from 2002 to 2004.Materials and Methods: The presence of an...

Hepatitis C virus (HCV) is a major human pathogen causing mild to severe liver disease worldwide. This positive strand RNA virus is remarkably efficient at establishing chronic infections. Although a high rate of genetic variability may facilitate viral escape and persistence in the face of Ag-specific immune responses, HCV may also encode proteins that facilitate evasion of immunological surve...