Tenapanor (RDX5791, AZD1722), a first-in-class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption of sodium and phosphate. It is being studied in patients with chronic kidney disease requiring dialysis, who are often administered phosphate binders such as sevelamer to help ...

The monocyte monolayer assay (MMA) is used to predict transfusion outcomes when antibodies red blood cell (RBC) antigens are present and compatible antigen-negative isn’t available. Typically, the monocytes peripheral mononuclear cells (PBMC) isolated from healthy volunteers. This study aimed determine between-volunteer variability in reactivity MMA. PBMCs were (Ficoll density gradient) freshly...

Aims: Flexibility and conformability are key performance characteristics in dressing design and construction, which can have an impact on product suitability in the clinical environment. This study evaluated both quantitatively and qualitatively the conformability and comfort of a variety of wound dressings (Biatain® Soft/Ag/Non-adhesive (Coloplast), Allevyn® Gentle (Smith and Nephew), Mepilex®...

Volunteer computing is an innovative approach to high performance computing that relies on volunteers who donate their personal computers’ unused resources to a computationally intensive research project. Prominent volunteer computing projects include SETI@home, Folding@Home, and The Great Internet Mersenne Prime Search (GIMPS). Many volunteer computing projects are built upon a volunteer compu...

Ramp rates for incremental ramp rate exercise testing are not standardised. The ramp rate may influence the values obtained during exercise testing. We compared a slow ramp rate (SR) (3watts/minute) to a fast ramp rate (FR) (20 watts/minute) in 8 fit non elite cyclists using cycle ergometry. We measured peak power ,oxygen consumption (VO2) at anaerobic threshold (AT) and maximum aerobic capacit...

In this study 6 CTX-M positive E. coli isolates collected during a clinical study examining the effect of antibiotic use in a human trial were analysed. The aim of the study was to analyse these isolates and assess the effect of full or partial loss of plasmid genes on bacterial fitness and pathogenicity. A DNA array was utilised to assess resistance and virulence gene carriage. Plasmids were c...

Background: Majority of high altitude residents have certain clinical, physiological, anatomical and biochemical changes. Pain threshold is one of the numerable changes that may occur due to chronic hypoxia. The aim of this research was to study the long term effects of high altitude exposure on pain perception among healthy volunteer subjects. Methods: This is an observational case-control stu...

Volunteers for prevention or screening trials are generally healthier and have lower mortality than the general population. The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) is an ongoing, multicenter, randomized trial that randomized 155,000 men and women aged 55-74 years to a screening or control arm between 1993 and 2001. The authors compared demographics, mortality r...

When predicting volunteer intention, much attention is paid to the volunteer organization environment (VOE). Given that self-efficacy and motivation have emerged as important predictors of volunteer intention, we adopted a combination of ideas of Bandura's social cognitive theory and Ajzen's theory of planned behavior integrating VOE, self-efficacy and motivation to examine their effects on vol...