Heart Failure (HF) is a complicated, fatal medical condition that poses severe threat to human life. It complex ailment can lead death and associated with high healthcare costs, significant morbidity mortality rates, reduction in functional capacity quality of Recent data analysis reveals approximately 64million people worldwide are affected by HF.1 Patients HFrEF benefit from cardiac contracti...

Abstract. Purpose of the work: to study indicators characterizing heart lesions in elderly patients who had carried COVID-19. Materials and methods: 86 older than 60 years old, were examined, whom 56 (32 women 24 men) have COVID-19 between 3 6 months before study, 30 (12 men 18 women) did not COVID - 19 anamnesis. The been examined clinically, electro echocardiography performed. results. Elderl...

The effects of isoproterenol and propranolol on the hemodynamics were evaluated in dogs for the purpose of their clinical application in the management of cardiovascular surgical patients. In dogs receiving 0.002 mgjkg of isoproterenol intravenously with one shot, marked positive inotropic and chronotropic responses were achieved in 5 seconds and returned to the control values in 5 minutes. Hea...

The study was conducted to determine the effects of boiled extract of Cleistanthus collinus on rats by observing ECG changes and electrolyte levels in serum and urine. Influence of minoxidil and glibenclamide on Cleistanthus collinus induced toxicity was determined. ED50 for arrhythmia, changes in contractility and heart rate were recorded using the isolated frog heart. Cleistanthus at low dose...

Background: There is an increasing popularity of waterpipe tobacco smoking (WTS) in youth and even inathletes worldwide. Despite the existence of evidence of the harmful effects of hookah smoke on varioussystems of the body, especially the cardiovascular system, its simultaneous effect with exercise training hasnot been well studi...

Elevated expression and activity of matrix metalloproteinase-9 (MMP9) and decreased contractility of cardiomyocytes are documented in diabetic hearts. However, it is unclear whether MMP is involved in the regulation of contractility of cardiomyocytes in diabetic hearts. In the present study, we tested the hypothesis that MMP9 regulates contractility of cardiomyocytes in diabetic hearts, and abl...

BACKGROUND Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis. We previously demonstrated that apelin is one of the most potent endogenous stimulators of cardiac contractility; however, its underlying signaling mechanisms remain largely elusive. In this study we characterized the contribution of protein kinase C ...

The following parameters were studied before and after acute occlusion of the anterior descending branch of the left coronary artery in 17 dogs: bradykinin (BK) in the coronary sinus blood, heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular max dp/dt (LV max dp/dt), and an index of myocardial contractility (LV max dp/dt/...

BACKGROUND Propofol, sevoflurane, and desflurane may cause hemodynamic compromise during anesthesia and critical care management. The aim of the study was to compare these anesthetics during increased dose and recovery to maintenance level. METHODS Anesthetized, open-chest New Zealand White rabbits were used to acquire dose-response curves with sevoflurane, desflurane, and propofol, followed ...