To survive adverse and ever-changing environmental conditions, an organism must be able to adapt. It has long been established that the cellular reaction to stress includes the upregulation of genes coding for specific stress-responsive factors. In the present study, we demonstrate that during the early steps of the heat stress response, 25% of the Arabidopsis seedling transcriptome is targeted...

Inflammatory mediators not only activate "pain-"sensing neurons, the nociceptors, to trigger acute pain sensations, more important, they increase nociceptor responsiveness to produce inflammatory hyperalgesia. For example, prostaglandins activate G(s)-protein-coupled receptors and initiate cAMP- and protein kinase A (PKA)-mediated processes. We demonstrate for the first time at the cellular lev...

Eukaryotic heat shock transcription factors (HSF) regulate an evolutionarily conserved stress-response pathway essential for survival against a variety of environmental and developmental stresses. Although the highly similar HSF family members have distinct roles in responding to stress and activating target gene expression, the mechanisms that govern these roles are unknown. Here we identify a...

Exposure of human cells to heat switches the activating signal of the DNA damage checkpoint from genotoxic to temperature stress. This change reduces mitotic commitment at the expense of DNA break repair. The thermal alterations behind this switch remain elusive despite the successful use of heat to sensitise cancer cells to DNA breaks. Rad9 is a highly conserved subunit of the Rad9-Rad1-Hus1 (...

Estimation of latent heat flux at the agricultural field scale is required for proper water management. The current generation thermal sensors except Landsat-8 provide data on the order of 1000 m. The aim of this study is to test three approaches based on contextual models using only remote sensing datasets for the disaggregation of latent heat flux over India. The first two approaches are, res...

Extreme heat poses significant risks to the world’s growing urban population, and the heat stress to human health is likely to escalate with the anthropogenically increased temperatures projected by climate models. Thus, the additional heat from the urban heat island (UHI) effect needs to be quantified, including the spatial pattern. This study focuses on the city of Valencia (Spain), investiga...

Present paper investigated the strain and damage sensing property on concrete cubes embedded with carbon fibers. Concrete cubes of dimension 150 mm have been casted with different concentration of carbon fibers to study the strain and damage sensing property under cyclic loading that can be further used for health monitoring as non-destructive testing (NDT) approach. All the specimens were test...