"Common red blood cell disorders encountered in the normal newborn nursery include hemolytic disease of the newborn and resultant hyperbilirubinemia, anemia, and polycythemia. A less frequent clinically relevant hematologic issue in newborns to be covered herein is thrombocytopenia."

Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia myelodysplastic syndromes. Researchers continue to explore their utility other hematologic solid tumors. Based on capacity compounds inhibit methyltransferase enzymes important role methylation health disease, it is essential understand molecular changes that azanuc...

The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of actin polymerization in hematopoietic cells. The dynamic nature of cytoskeletal changes during a variety of cellular processes demands complex mechanisms for coordinated integration of input signals, precise localization within the cell, and regulated activation of the Arp2/3 complex. Mutations in the Wiskott-Aldrich syndrome gen...

Pleural involvement secondary to Multiple Myeloma is considered a very rare complication. According to the literature only 1% of these patients develop a myelomatous pleural effusion. We present a case of a 39 year old man with multiple myeloma diagnosed six years prior to our evaluation, which developed progressive dyspnea, dry cough and right pleuritic chest pain two weeks prior to admission....

a unique case of xanthoma in the external ear canal pediatric patient is presented this report. We describe and resume current literature on xanthomas head neck area. clinical intraoperative findings are reported presumed mechanisms for emergence discussed. furthermore described pathologic immunohistochemical characteristics. mostly seen patients with lipid metabolism disorders or hyperlipidemi...

Linkage analysis was performed on a large pedigree with an autosomal dominant platelet disorder and a striking propensity in affected family members to develop hematologic malignancy, predominantly acute myelogenous leukemia. We report the linkage of the autosomal dominant platelet disorder to markers on chromosome 21q22. Four genetic markers completely cosegregate with the trait and yield maxi...

Organic solvents have long been recognized as being toxic to multiple organ systems. It is commonly known that exposure to organic solvents causes hematologic diseases, including hematologic cancers such as leukemia and lymphoma. A large body of literature has developed which shows that exposure to organic solvents causes kidney disease, especially chronic glomerulonephritis. A number of recent...

Monoclonal gammopathies comprise a group of disorders characterized by the neoplastic proliferation of a single clone of plasma cells. Multiple myeloma (MM; plasma-cell myeloma, myelomatosis, Kahler’s disease) is the prototype of monoclonal plasma cell disorders, accounting for 1% of all newly diagnosed cancers and 10% of all hematologic malignancies. It is the second most frequent hematologic ...

methods: in a retrospective descriptive study, medical records of 204 hip fractured patients with the age of 60 or older who were admitted to the department of orthopedics was considered regarding routine laboratory tests. predictive values of these tests were assessed using receiver operating characteristic curve (roc).  results: the incidence of death due to hip fracture was 24%. the mortalit...

introduction: homeopathy can be applied to treat various diseases and conditions such as cancer, allergy, mood disorders, headache and pain. this case showed that homeopathic medicine can be a treatment modality for idiopathic thrombocytopenic purpura (itp), an autoimmune-mediated hematologic disorder. case presentation: the patient was a 5.5–year-old child with itp who referred to the homeopat...