background & aim: vast variety of plants in various regions of the country and lack of enough information on their chemical combinations, sometimes lead to triggering poisoning and unsatisfied complications. regarding to fabulous herbal characteristics of hypricum, many research about poisoning and side effects of high concentrations of h. scabrum have not taken place until now. therefore r...

In this study we investigated the correlation between donor chimerism status and disease relapse following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The chimerism of Fluorescence-activated cell sorter (FACS) sorted CD3+T lymphocytes of 153 cases, CD56+CD16+NK lymphocytes of 153 cases and CD19+B lymphocytes of 31 cases with acute B lymphoblastic leukemia (B-ALL) was analyze...

Touch MEdical MEdia 43 Multiple myeloma (MM) is an incurable plasma cell disease that comprises 1 % of all cancers and 10 % of hematologic malignancies. It primarily affects older individuals—the median age at the moment of diagnosis is 70 years—and two-thirds of multiple myeloma patients are over 65 years of age when they are first diagnosed. The outcome of MM patients has significantly improv...

Hematological emergencies are defined as acute life-threatening conditions in hematological diseases due to benign blood disorders or hematological malignancies or as a result of its treatment. This article deals of the most common emergencies encountered by hematologists. Emerging clinical situations, predictable or not, are common in the treatment of hematological diseases. However, the rapid...

Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian neoplasm. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Despite the rarity o...

this is a mortality study in internal medicine wards of amir-alam hospital, since the beginning of 1374 to end of 1376. here, we reviewed, prevalence of disease lead to death, the ward and invasive interventions and duration of admission of patients before death. in this study, records of 85 patients were reviewed. 68.2% of patients were men and 31.8% women. mean of age was 61.6% with minimum o...

Hematopoiesis is the formation of cellular components of the blood from a small population of pluripotential stem cells, which are formed in embryonic life and persist thereafter through self-regeneration. When stimulated by hematopoietic growth factors such as cytokines, these precursor cells give rise to progenitor cells committed to development along specific pathways. These progenitor cells...

Dear Editor, Translocation t(8;9)(p22;p24) has been reported in diverse hematologic neoplasms, including acute leukemia, myeloproliferative neoplasm (MPN), and myelodysplastic syndromes/myeloproliferative neoplasm. These findings indicate that the mutation occurs in pluripotent, lymphoid-myeloid stem cells [1]. The pericentriolar material 1 (PCM1) gene, located on chromosome 8p22, encodes a pro...