Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy limited by graft-versus-host disease (GVHD). This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. The receptor channel P2X7 and ligand adenosine 5’-triphosphate (ATP) have been implicated in GVHD patho...